| 1 |
33289420 | Tissue and interspecies comparison of catechol-O-methyltransferase mediated catalysis of 6-O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone. | 2021 Mar |
3 |
| 2 |
33675481 | Entacapone scavenges peroxynitrite and protects against kidney and liver injuries induced by renal ischemia/reperfusion in rats. | 2021 Aug |
2 |
| 3 |
32299731 | Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase. | 2020 Jun 15 |
1 |
| 4 |
31109396 | Development and validation of a HPLC electrochemical detection method to measure COMT activity as a tool in drug development. | 2019 May 1 |
2 |
| 5 |
25435314 | Dopamine bioavailability in the mPFC modulates operant learning performance in rats: an experimental study with a computational interpretation. | 2015 Mar 1 |
1 |
| 6 |
25834315 | Effect of entacapone on colon motility and ion transport in a rat model of Parkinson's disease. | 2015 Mar 28 |
2 |
| 7 |
24928742 | Metabolite profiling analysis of FR429, an ellagitannin purified from Polygonum capitatum, in rat and human liver microsomes, cytosol and rat primary hepatocytes in vitro. | 2014 Sep 5 |
3 |
| 8 |
23104937 | Endothelial dysfunction in gestational hypertension induced by catechol-O-methyltransferase inhibition. | 2013 Mar |
1 |
| 9 |
22999990 | Pharmacokinetic study of luteolin, apigenin, chrysoeriol and diosmetin after oral administration of Flos Chrysanthemi extract in rats. | 2012 Dec |
2 |
| 10 |
21209248 | Role of catechol-O-methyltransferase in the disposition of luteolin in rats. | 2011 Apr |
1 |
| 11 |
21501335 | Entacapone promotes cAMP-dependent colonic Cl(-) secretion in rats. | 2011 Jul |
2 |
| 12 |
19629963 | Simultaneous analysis of catechol-O-methyl transferase activity, S-adenosylhomocysteine and adenosine. | 2010 Mar |
2 |
| 13 |
19783845 | Capture compound mass spectrometry sheds light on the molecular mechanisms of liver toxicity of two Parkinson drugs. | 2010 Jan |
2 |
| 14 |
19879254 | Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus. | 2010 Jan 14 |
2 |
| 15 |
21095463 | Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of L-dopa treatment. | 2010 |
1 |
| 16 |
19894644 | Establishing the probable mechanism of L-DOPA in Alzheimer's disease management. | 2009 Sep-Oct |
1 |
| 17 |
18074122 | The relationship between core body temperature and 3,4-methylenedioxymethamphetamine metabolism in rats: implications for neurotoxicity. | 2008 Apr |
1 |
| 18 |
17408604 | Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. | 2007 May 1 |
2 |
| 19 |
16437585 | Coadministration of entacapone with levodopa attenuates the severity of dyskinesias in hemiparkinsonian rats. | 2006 May |
3 |
| 20 |
15614425 | The COMT inhibitor, entacapone, reduces levodopa-induced elevations in plasma homocysteine in healthy adult rats. | 2005 Sep |
2 |
| 21 |
15698633 | Early administration of entacapone prevents levodopa-induced motor fluctuations in hemiparkinsonian rats. | 2005 Mar |
2 |
| 22 |
15784340 | The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration. | 2005 Apr |
6 |
| 23 |
15502970 | Entacapone increases and prolongs the central effects of l-DOPA in the 6-hydroxydopamine-lesioned rat. | 2004 Nov |
2 |
| 24 |
12538800 | Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat. | 2003 Feb |
6 |
| 25 |
12573869 | Effects of peripheral and central catechol-O-methyltransferase inhibition on striatal extracellular levels of dopamine: a microdialysis study in freely moving rats. | 2003 Jan |
2 |
| 26 |
14654757 | Entacapone protects from angiotensin II-induced inflammation and renal injury. | 2003 Dec |
3 |
| 27 |
11806720 | Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase. | 2002 Jan 31 |
1 |
| 28 |
12111468 | Different modes of action of catecholamine-O-methyltransferase inhibitors entacapone and tolcapone on adenylyl cyclase activity in vitro. | 2002 May |
4 |
| 29 |
12180806 | Entacapone does not induce conformational changes in liver mitochondria or skeletal muscle in vivo. | 2002 Jul |
2 |
| 30 |
12393055 | Effects of entacapone and tolcapone on mitochondrial membrane potential. | 2002 Oct 18 |
2 |
| 31 |
12403054 | Pharmacodynamic response of entacapone in rats after administration of entacapone formulations and prodrugs with varying bioavailabilities. | 2002 Jun |
4 |
| 32 |
12454735 | Different toxicological profile of two COMT inhibitors in vivo: the role of uncoupling effects. | 2002 Nov |
2 |
| 33 |
11261749 | Comparative toxicological study on the hepatic safety of entacapone and tolcapone in the rat. | 2001 |
3 |
| 34 |
11314772 | The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats. | 2001 |
1 |
| 35 |
11318939 | D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors. | 2001 May |
2 |
| 36 |
11510881 | The role of dopamine-metabolizing enzymes in the regulation of renal sodium excretion in the rat. | 2001 Jul |
1 |
| 37 |
11732751 | Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs. | 2001 Nov |
2 |
| 38 |
9597116 | Different renal effects of two inhibitors of catechol-O-methylation in the rat: entacapone and CGP 28014. | 1998 Apr |
1 |
| 39 |
9610919 | Conditioned place preference induced by a combination of L-dopa and a COMT inhibitor, entacapone, in rats. | 1998 May |
4 |
| 40 |
9105581 | Effects of selective catechol-O-methyltransferase inhibitors on single-trial passive avoidance retention in male rats. | 1997 Jun |
1 |
| 41 |
9358559 | Glucuronidation of entacapone, nitecapone, tolcapone, and some other nitrocatechols by rat liver microsomes. | 1997 Oct |
3 |
| 42 |
9537825 | Entacapone, a novel catechol-O-methyltransferase inhibitor for Parkinson's disease, does not impair mitochondrial energy production. | 1997 Dec 11 |
1 |
| 43 |
7518301 | Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats. | 1994 May |
3 |
| 44 |
8001593 | Metabolite profiles of two [14C]-labelled catechol O-methyltransferase inhibitors, nitecapone and entacapone, in rat and mouse urine and rat bile. | 1994 Apr-Jun |
1 |
| 45 |
8082707 | Effect of catechol-O-methyl transferase inhibition on peripheral and central metabolism of 6-[18F]fluoro-L-dopa. | 1994 May 12 |
1 |
| 46 |
8095232 | Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans. | 1993 Jan-Feb |
1 |
| 47 |
1407012 | Biochemical and pharmacological properties of a peripherally acting catechol-O-methyltransferase inhibitor entacapone. | 1992 Sep |
7 |
| 48 |
1628144 | Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat. | 1992 Mar |
1 |
| 49 |
2501597 | Computerized rotometer apparatus for recording circling behavior. | 1989 Jun |
2 |