| 1 |
25409768 | Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat. | 2015 Apr |
1 |
| 2 |
25869243 | Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats. | 2015 |
3 |
| 3 |
26622527 | Dynamic changes of five neurotransmitters and their related enzymes in various rat tissues following β-asarone and levodopa co-administration. | 2015 Oct |
2 |
| 4 |
24910244 | Coadministration of β-asarone and levodopa increases dopamine in rat brain by accelerating transformation of levodopa: a different mechanism from Madopar. | 2014 Sep |
2 |
| 5 |
24997271 | Neurons expressing individual enzymes of dopamine synthesis in the mediobasal hypothalamus of adult rats: functional significance and topographic interrelations. | 2014 Sep 26 |
1 |
| 6 |
21095463 | Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of L-dopa treatment. | 2010 |
2 |
| 7 |
19894644 | Establishing the probable mechanism of L-DOPA in Alzheimer's disease management. | 2009 Sep-Oct |
1 |
| 8 |
16437585 | Coadministration of entacapone with levodopa attenuates the severity of dyskinesias in hemiparkinsonian rats. | 2006 May |
4 |
| 9 |
15614425 | The COMT inhibitor, entacapone, reduces levodopa-induced elevations in plasma homocysteine in healthy adult rats. | 2005 Sep |
2 |
| 10 |
15698633 | Early administration of entacapone prevents levodopa-induced motor fluctuations in hemiparkinsonian rats. | 2005 Mar |
2 |
| 11 |
15502970 | Entacapone increases and prolongs the central effects of l-DOPA in the 6-hydroxydopamine-lesioned rat. | 2004 Nov |
3 |
| 12 |
12421594 | Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicity. | 2003 Jan |
10 |
| 13 |
12573869 | Effects of peripheral and central catechol-O-methyltransferase inhibition on striatal extracellular levels of dopamine: a microdialysis study in freely moving rats. | 2003 Jan |
1 |
| 14 |
12660477 | BIA 3-202, a novel catechol-O-methyltransferase inhibitor, reduces the peripheral O-methylation of L-DOPA and enhances its availability to the brain. | 2003 May |
8 |
| 15 |
12711835 | Quercetin potentiates L-Dopa reversal of drug-induced catalepsy in rats: possible COMT/MAO inhibition. | 2003 Jun |
1 |
| 16 |
12787259 | Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone). | 2003 Jun |
4 |
| 17 |
11942697 | Dopaminergic transmission in the rat striatum in vivo in conditions of pharmacological modulation. | 2002 Mar-Apr |
2 |
| 18 |
12111468 | Different modes of action of catecholamine-O-methyltransferase inhibitors entacapone and tolcapone on adenylyl cyclase activity in vitro. | 2002 May |
6 |
| 19 |
12180806 | Entacapone does not induce conformational changes in liver mitochondria or skeletal muscle in vivo. | 2002 Jul |
2 |
| 20 |
12393055 | Effects of entacapone and tolcapone on mitochondrial membrane potential. | 2002 Oct 18 |
2 |
| 21 |
11261749 | Comparative toxicological study on the hepatic safety of entacapone and tolcapone in the rat. | 2001 |
2 |
| 22 |
11314772 | The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats. | 2001 |
5 |
| 23 |
11412836 | BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation. | 2001 May 18 |
1 |
| 24 |
11732751 | Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs. | 2001 Nov |
2 |
| 25 |
10608486 | Microdialysis studies on the action of tolcapone on pharmacologically-elevated extracellular dopamine levels in conscious rats. | 1999 Nov |
1 |
| 26 |
10651109 | Inhibition of catechol-O-methyltransferase (COMT) in the brain does not affect the action of dopamine and levodopa: an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons. | 1999 |
1 |
| 27 |
9037574 | Effect of L-Dopa and the catechol-O-methyltransferase inhibitor Ro 41-0960 on sulfur amino acid metabolites in rats. | 1997 Feb |
1 |
| 28 |
9085195 | Peripheral and central inhibitors of catechol-O-methyl transferase: effects on liver and brain COMT activity and L-DOPA metabolism. | 1997 |
1 |
| 29 |
8976015 | Catechol-O-methyltransferase inhibition increases the uptake of 11C-3-(3,4-dihydroxyphenyl)-L-alanine in the rat pancreas. | 1996 Dec |
1 |
| 30 |
7768276 | Beneficial effects of co-administration of catechol-O-methyltransferase inhibitors and L-dihydroxyphenylalanine in rat models of depression. | 1995 Feb 14 |
1 |
| 31 |
7518301 | Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats. | 1994 May |
4 |
| 32 |
7945976 | 3-O-methyl-DOPA is not involved in the development of behavioral supersensitivity after repeated L-dopa administration in 6-OHDA lesioned rats. | 1994 Jul 29 |
1 |
| 33 |
8119326 | Effects of three types of catechol O-methylation inhibitors on L-3,4-dihydroxyphenylalanine-induced circling behaviour in rats. | 1993 Nov 30 |
1 |
| 34 |
8370570 | Dopamine formation, from its immediate precursor 3,4-dihydroxyphenylalanine, along the rat digestive tract. | 1993 |
2 |
| 35 |
8417137 | Effects of catechol-O-methyltransferase inhibitors and L-3,4-dihydroxyphenylalanine with or without carbidopa on extracellular dopamine in rat striatum. | 1993 Jan |
1 |
| 36 |
1300941 | Neurochemical and psychomotor interactions of new selective COMT inhibitors with clorgyline and nomifensine in levodopa-treated rats and mice. | 1992 Nov-Dec |
2 |
| 37 |
1549240 | Catechol-O-methyltransferase inhibition increases striatal L-dopa and dopamine: an in vivo study in rats. | 1992 Mar |
3 |
| 38 |
1613509 | Extracellular concentrations of dopamine and metabolites in the rat caudate after oral administration of a novel catechol-O-methyltransferase inhibitor Ro 40-7592. | 1992 Jul |
1 |
| 39 |
1766471 | Effect of high single doses of levodopa and carbidopa on brain dopamine and its metabolites: modulation by selective inhibitors of monoamine oxidase and/or catechol-O-methyltransferase in the male rat. | 1991 Oct |
4 |
| 40 |
2113389 | Effect of acute levodopa on brain catecholamines after selective MAO and COMT inhibition in male rats. | 1990 |
1 |
| 41 |
2128510 | Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and O-methylation of exogenous L-dopa in the rat. | 1990 |
1 |
| 42 |
2501597 | Computerized rotometer apparatus for recording circling behavior. | 1989 Jun |
1 |
| 43 |
3171977 | Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's disease. | 1988 Oct |
1 |
| 44 |
2960778 | Potentiation of central effects of L-dopa by an inhibitor of catechol-O-methyltransferase. | 1987 |
2 |
| 45 |
7121609 | Catechol-O-methyltransferase inhibition by U-0521 increases striatal utilization of levodopa. | 1982 Jul |
1 |
| 46 |
593428 | Methoxytyrosine formation as an indicator of catechol-O-methyltransferase activity in rat liver in vivo. | 1977 Oct |
1 |