| 1 |
33289420 | Tissue and interspecies comparison of catechol-O-methyltransferase mediated catalysis of 6-O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone. | 2021 Mar |
3 |
| 2 |
32474681 | Novel, non-nitrocatechol catechol-O-methyltransferase inhibitors modulate dopamine neurotransmission in the frontal cortex and improve cognitive flexibility. | 2020 Sep |
2 |
| 3 |
31231499 | Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naïve but not in haloperidol challenged rats. | 2019 Jun |
3 |
| 4 |
31491076 | Development of a PC12 Cell Based Assay for Screening Catechol-O-methyltransferase Inhibitors. | 2019 Oct 16 |
1 |
| 5 |
29310047 | Differential COMT expression and behavioral effects of COMT inhibition in male and female Wistar and alcohol preferring rats. | 2018 Mar |
2 |
| 6 |
30406194 | COMT Inhibition Alters Cue-Evoked Oscillatory Dynamics during Alcohol Drinking in the Rat. | 2018 Sep-Oct |
2 |
| 7 |
26919286 | Brain catechol-O-methyltransferase (COMT) inhibition by tolcapone counteracts recognition memory deficits in normal and chronic phencyclidine-treated rats and in COMT-Val transgenic mice. | 2016 Aug |
4 |
| 8 |
27463695 | Development of Blood-Brain Barrier Permeable Nitrocatechol-Based Catechol O-Methyltransferase Inhibitors with Reduced Potential for Hepatotoxicity. | 2016 Aug 25 |
1 |
| 9 |
25799918 | Putative therapeutic targets for symptom subtypes of adult ADHD: D4 receptor agonism and COMT inhibition improve attention and response inhibition in a novel translational animal model. | 2015 Apr |
1 |
| 10 |
24465516 | Metabolism of N-acylated-dopamine. | 2014 |
1 |
| 11 |
24997271 | Neurons expressing individual enzymes of dopamine synthesis in the mediobasal hypothalamus of adult rats: functional significance and topographic interrelations. | 2014 Sep 26 |
1 |
| 12 |
25257296 | Tolcapone suppresses ethanol intake in alcohol-preferring rats performing a novel cued access protocol. | 2014 Sep |
2 |
| 13 |
23543593 | Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD/Mhm (cy/+) substrain of the Hannover Sprague-Dawley rat. | 2013 Aug |
3 |
| 14 |
23567203 | Opposite effects of tolcapone on amphetamine-disrupted startle gating in low vs. high COMT-expressing rat strains. | 2013 May |
1 |
| 15 |
23613951 | Sexually dimorphic effects of catechol-O-methyltransferase (COMT) inhibition on dopamine metabolism in multiple brain regions. | 2013 |
2 |
| 16 |
19783845 | Capture compound mass spectrometry sheds light on the molecular mechanisms of liver toxicity of two Parkinson drugs. | 2010 Jan |
2 |
| 17 |
20870159 | Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957. | 2010 Oct |
2 |
| 18 |
18854987 | Tolcapone enhances food-evoked dopamine efflux and executive memory processes mediated by the rat prefrontal cortex. | 2009 Jan |
1 |
| 19 |
19615953 | Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis. | 2009 Aug 15 |
2 |
| 20 |
15784340 | The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration. | 2005 Apr |
5 |
| 21 |
15190105 | Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. | 2004 Jun 9 |
1 |
| 22 |
12538800 | Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat. | 2003 Feb |
7 |
| 23 |
12573869 | Effects of peripheral and central catechol-O-methyltransferase inhibition on striatal extracellular levels of dopamine: a microdialysis study in freely moving rats. | 2003 Jan |
5 |
| 24 |
11806720 | Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase. | 2002 Jan 31 |
1 |
| 25 |
11942697 | Dopaminergic transmission in the rat striatum in vivo in conditions of pharmacological modulation. | 2002 Mar-Apr |
3 |
| 26 |
12111468 | Different modes of action of catecholamine-O-methyltransferase inhibitors entacapone and tolcapone on adenylyl cyclase activity in vitro. | 2002 May |
3 |
| 27 |
12180806 | Entacapone does not induce conformational changes in liver mitochondria or skeletal muscle in vivo. | 2002 Jul |
2 |
| 28 |
12393055 | Effects of entacapone and tolcapone on mitochondrial membrane potential. | 2002 Oct 18 |
2 |
| 29 |
12454735 | Different toxicological profile of two COMT inhibitors in vivo: the role of uncoupling effects. | 2002 Nov |
2 |
| 30 |
11261749 | Comparative toxicological study on the hepatic safety of entacapone and tolcapone in the rat. | 2001 |
3 |
| 31 |
11314772 | The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats. | 2001 |
1 |
| 32 |
11318939 | D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors. | 2001 May |
2 |
| 33 |
11489299 | Effect of intracerebral 6-nitronoradrenaline, an endogenous catechol-O-methyltransferase (COMT) inhibitor, on striatal dopamine metabolism in anaesthetised rats. | 2001 Aug 15 |
1 |
| 34 |
11081220 | [Pharmacological modulation of dopaminergic transmission in the rat striatum in vivo]. | 2000 Sep |
2 |
| 35 |
10064789 | Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase. | 1999 Mar 6 |
1 |
| 36 |
10323260 | Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake. | 1999 Apr 9 |
2 |
| 37 |
10651109 | Inhibition of catechol-O-methyltransferase (COMT) in the brain does not affect the action of dopamine and levodopa: an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons. | 1999 |
2 |
| 38 |
9460702 | Inhibitors of catecholamine metabolizing enzymes cause changes in S-adenosylmethionine and S-adenosylhomocysteine in the rat brain. | 1998 Jan |
1 |
| 39 |
9774242 | No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: a microdialysis study in anaesthetized rats. | 1998 Sep 4 |
1 |
| 40 |
9030401 | Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats. | 1997 Jan |
1 |
| 41 |
9141056 | Effect of tolcapone on plasma and striatal apomorphine disposition in rats. | 1997 Mar 3 |
1 |
| 42 |
9262345 | Studies on the tight-binding nature of tolcapone inhibition of soluble and membrane-bound rat brain catechol-O-methyltransferase. | 1997 Aug |
4 |
| 43 |
9358559 | Glucuronidation of entacapone, nitecapone, tolcapone, and some other nitrocatechols by rat liver microsomes. | 1997 Oct |
3 |
| 44 |
9483396 | [Microdialysis study of tolcapone effect during blockage of neuronal dopamine reuptake caused by GBR-12909]. | 1997 Sep-Oct |
2 |
| 45 |
8821542 | Ontogenic aspects of liver and kidney catechol-O-methyltransferase sensitivity to tolcapone. | 1996 Feb |
9 |
| 46 |
8829199 | Minor effect of tolcapone, a catechol-O-methyltransferase inhibitor, on extracellular dopamine levels modified by amphetamine or pargyline: a microdialysis study in anaesthetized rats. | 1996 Jun |
1 |
| 47 |
7570359 | Distinct pharmacological regulation of evoked dopamine efflux in the amygdala and striatum of the rat in vivo. | 1995 Jul |
1 |
| 48 |
7674141 | Lack of an effect of Madopar on the disposition of tolcapone and its 3-O-methylated metabolite in rats. | 1995 Jun |
1 |
| 49 |
7737328 | Effects of tolcapone, a novel catechol-O-methyltransferase inhibitor, on striatal metabolism of L-dopa and dopamine in rats. | 1995 Feb 6 |
2 |
| 50 |
7996385 | The disposition of the tolcapone 3-O-methylated metabolite is affected by the route of administration in rats. | 1994 Jul |
4 |