Phenobarbital

cytochrome P450, family 21, subfamily a, polypeptide 1 ; Mus musculus







67 Article(s)
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1 26400395 Dose of Phenobarbital and Age of Treatment at Early Life are Two Key Factors for the Persistent Induction of Cytochrome P450 Enzymes in Adult Mouse Liver. 2015 Dec 1
2 24180433 Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. 2014 Jan 4
3 23475686 Isolation of mouse hepatocytes. 2013 1
4 12076846 Influence of cytochrome P450 induction on the pharmacokinetics and pharmacodynamics of remacemide hydrochloride. 2002 May 1
5 9685045 Investigation of hepatic cytochrome P-450 enzyme induction and DNA adduct formation in male CD/1 mice following oral administration of toxaphene. 1998 May-Jun 2
6 9007046 Induction and inhibition of mouse cytochrome P-450 2B enzymes by musk xylene. 1997 Jan 1
7 9357489 Studies of the hepatic mitochondrial and microsomal mixed-function oxidase system during Plasmodium yoelii infection and inducer treatment in Swiss albino mice. 1997 Oct 1
8 8646785 An ESR and spectrophotometric study of the denitration of nitroheterocyclic drugs by liver homogenates and their metabolic consumption by liver microsomes from cytochrome P-450-induced mice. 1996 Mar 25 2
9 8713075 Genetic analysis of the phenobarbital regulation of the cytochrome P-450 2b-9 and aldehyde dehydrogenase type 2 mRNAs in mouse liver. 1996 Jul 15 1
10 8795461 Prevention of naphthalene-induced cataract and hepatic glutathione loss by the L-cysteine prodrugs, MTCA and PTCA. 1996 Apr 1
11 8907578 Modulation of constitutive and inducible hepatic cytochrome(s) P-450 by interferon beta in mice. 1996 Feb 1
12 7575638 Induction of cytochrome P-4502B1-related mouse cytochrome P-450 and regulation of its expression by epidermal growth factor/transforming growth factor alpha in primary hepatocyte culture. 1995 Sep 7 2
13 1552174 Relation between cytochrome P-450 increase and endoplasmic reticulum proliferation in hepatocytes of mice treated with phenobarbital: a microphotometric and morphometric study. 1992 Mar 1
14 1933335 Protection and potentiation of MPTP-induced toxicity by cytochrome P-450 inhibitors and inducer: in vitro studies with brain slices. 1991 Aug 2 1
15 2117068 Bioactivation of 8-methoxypsoralen and irreversible inactivation of cytochrome P-450 in mouse liver microsomes: modification by monoclonal antibodies, inhibition of drug metabolism and distribution of covalent adducts. 1990 Aug 1
16 2212619 Microphotometric analysis of cytochrome P-450 in periportal, midzonal, and perivenular hepatocytes of mice treated with phenobarbital. 1990 Nov 3
17 2242403 Effect of cytochrome P-450 inhibition and stimulation on intensity of polyethylene degradation in microsomal fraction of mouse and rat livers. 1990 Sep 1
18 2268369 Immunochemical detection of human liver cytochrome P450 forms related to phenobarbital-inducible forms in the mouse. 1990 Dec 1 1
19 2319474 Covalent binding of phenytoin to protein and modulation of phenytoin metabolism by thiols in A/J mouse liver microsomes. 1990 Mar 1
20 2369784 Hepatic microsomal warfarin metabolism in warfarin-resistant and susceptible mouse strains: influence of pretreatment with cytochrome P-450 inducers. 1990 2
21 20702222 The in vitro effects and metabolism-mediated cytotoxicity of phorone, a glutathione-depleting agent. 1990 1
22 2779523 Purification and characterization of a mouse liver cytochrome P-450 induced by cannabidiol. 1989 Sep 1
23 2803241 High activity of cytochrome P-450-linked aminopyrine N-demethylase in mouse brain microsomes, and associated sex-related difference. 1989 Aug 1 3
24 2804167 [The effect of phenobarbital and amidopyrine on the rate of decomposition of isoforms of cytochrome P-450 in mouse liver microsomes]. 1989 Jul 4
25 2804321 [Induction of cytochrome P-450 in rat liver microsomes by perfluorodecalin]. 1989 Aug 1
26 2819695 Comparison of the effects of acute and subacute treatment of phenobarbital in different strains of mice. 1989 Nov 15 1
27 2451633 Cytochrome P-450 gene expression in the functional units of the fetal liver. 1988 Mar-Apr 1
28 2462160 Distribution and induction sites of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 in murine liver: immunohistochemical localization with monoclonal antibodies. 1988 Dec 1
29 2903743 Mouse hepatic cytochrome P-450 isozyme induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, pyrazole, and phenobarbital. 1988 Nov 1 1
30 3058117 Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy. 1988 Sep 15 1
31 3219345 Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA. 1988 Aug 23 1
32 3354230 Stereospecificity in the oxidation of phorate and phorate sulphoxide by purified FAD-containing mono-oxygenase and cytochrome P-450 isozymes. 1988 Jan 1
33 3370247 [Comparison of cytochrome P-450 forms induced by phenobarbital and 1,4-bis[3,5-dichloropyridyloxy)]benzene in the mouse and rat liver]. 1988 Feb 2
34 3390203 Loss of 3-methylcholanthrene-inducible form of cytochrome P-450 in liver microsomes following administration of carbon disulfide in C57BL/6 Cr mice. 1988 Jun 15 1
35 2833324 Hepatic drug metabolism and the activities of NADPH generating enzymes and glucose-6-phosphatase in phenobarbital treated genetically obese (ob/ob) mice. 1987 3
36 3030329 In vitro metabolism of etoposide (VP-16-213) by liver microsomes and irreversible binding of reactive intermediates to microsomal proteins. 1987 Feb 15 1
37 3106031 Microsomal ethanol-oxidizing system. 1987 1
38 3564013 The effects of differential induction of cytochrome P-450, carboxylesterase and glutathione S-transferase activities on malathion toxicity in mice. 1987 Mar 15 1
39 3629598 Metabolic activation of the pesticide azinphos-methyl by perfused mouse livers. 1987 Sep 15 1
40 3806412 A novel mechanism for the enhancement of acetaminophen hepatotoxicity by phenobarbital. 1987 Feb 2
41 2422427 Kinetics of depression and recovery of murine hepatic cytochrome P-450 levels after treatment with the interferon inducer polyriboinosinic-polyribocytidylic acid. 1986 May 1
42 3012058 Effects of two cannabinoids on hepatic microsomal cytochrome P-450. 1986 Jan 2
43 3271881 Cytochrome P-450-mediated denitrification of 2-nitropropane in mouse liver microsomes. 1986 Sep 2
44 3707601 Interactions of diethylphenylphosphine with purified, reconstituted mouse liver cytochrome P-450 monooxygenase systems. 1986 May 15 4
45 3731348 Different depressing effects of lentinan on the increases of cytochrome P-450-dependent monooxygenase activities induced in mice by phenobarbital and by 3-methylcholanthrene. 1986 Mar 1
46 3753840 Female-predominant expression of testosterone 16 alpha-hydroxylase ("I"-P-450(16)alpha) and its repression in strain 129/J. 1986 Feb 1 1
47 3764930 The effects of phenobarbital pretreatment on the metabolism and acute toxicity of the pesticide parathion in the mouse. 1986 Oct 2
48 3947732 [Effect of amidopyrine on the rate of cytochrome P-450 isoform breakdown]. 1986 Feb 2
49 2861996 Regulation of hepatic monooxygenases by phenobarbital, 3-methylcholanthrene, and polychlorinated biphenyls in rapid and slow acetylator mice. 1985 May-Jun 2
50 3966918 Induction of liver cytochrome P-450 in mice by warfarin. Comparison of warfarin-, phenobarbitone-, and cobalt-induced hepatic microsomal protein patterns by PAGE after partial purification on octyl-sepharose CL-4B. 1985 Jan 1 1