2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline

cytochrome P450 family 1 subfamily A member 2 ; Homo sapiens







16 Article(s)
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Pub. Year
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1 28879062 A modeling approach to evaluate the balance between bioactivation and detoxification of MeIQx in human hepatocytes. 2017 2
2 20004212 Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx). 2010 Feb 3 2
3 20307560 Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells. 2010 Jun 1 1
4 12351158 Metabolism of heterocyclic aromatic amines by human hepatocytes and cytochrome P4501A2. 2002 Sep 30 1
5 11258970 Metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxification pathway catalyzed by cytochrome P450 1A2. 2001 Feb 1
6 11453738 Regioselective differences in C(8)- and N-oxidation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2. 2001 Jul 1
7 10537291 N-oxidative metabolism of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in humans: excretion of the N2-glucuronide conjugate of 2-hydroxyamino-MeIQx in urine. 1999 Oct 15 4
8 9202738 Assessing human risk to heterocyclic amines. 1997 May 12 1
9 9270013 Urinary excretion of unmetabolized and phase II conjugates of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in humans: relationship to cytochrome P4501A2 and N-acetyltransferase activity. 1997 Aug 15 3
10 8678801 Chemical methods for assessing systemic exposure to dietary heterocyclic amines in man. 1996 1
11 7586210 Lower levels of urinary 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) in humans with higher CYP1A2 activity. 1995 Nov 6
12 8844810 Systemic exposure to dietary heterocyclic amines in man. 1995 1
13 8012961 Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. 1994 Jul 1 2
14 8261468 CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans. 1994 Jan 1 1
15 8472319 Human hepatic CYP1A1 and CYP1A2 content, determined with specific anti-peptide antibodies, correlates with the mutagenic activation of PhIP. 1993 Apr 2
16 1473228 N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver. 1992 Dec 2