| 1 |
35246464 | Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human Hepatocytes. | 2022 May |
1 |
| 2 |
35599345 | In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions. | 2022 Jun |
1 |
| 3 |
30390556 | Study on the inhibitory effect of furafylline and troleandomycin in the 7-methoxyresorufin-O-demethylase and nifedipine oxidase activities in hepatic microsomes from four poultry species using high-performance liquid chromatography coupled with fluorescence and ultraviolet detection. | 2019 Feb 5 |
2 |
| 4 |
29785610 | Evaluation of Strategies for the Assessment of Drug-Drug Interactions Involving Cytochrome P450 Enzymes. | 2018 Dec |
1 |
| 5 |
26856397 | Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3. | 2016 Mar |
1 |
| 6 |
23898916 | DNA adducts of the tobacco carcinogens 2-amino-9H-pyrido[2,3-b]indole and 4-aminobiphenyl are formed at environmental exposure levels and persist in human hepatocytes. | 2013 Sep 16 |
1 |
| 7 |
22266842 | Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. | 2012 Apr |
1 |
| 8 |
23106957 | In vitro characterization of the oxidation of a pyridinium metabolite of haloperidol by human placenta: the effect of smoking. | 2012 |
2 |
| 9 |
21336516 | Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity. | 2011 Mar |
1 |
| 10 |
21726170 | In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450. | 2011 Nov |
1 |
| 11 |
21755496 | Development of a whole-cell screening system for evaluation of the human CYP1A2-mediated metabolism. | 2011 Dec |
1 |
| 12 |
19204080 | A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes. | 2009 May |
1 |
| 13 |
17823234 | Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation? | 2007 Dec |
1 |
| 14 |
16771648 | Enhancing the drug metabolism activities of C3A--a human hepatocyte cell line--by tissue engineering within alginate scaffolds. | 2006 May |
1 |
| 15 |
16814747 | Metabolism of the soyabean isoflavone daidzein by CYP1A2 and the extra-hepatic CYPs 1A1 and 1B1 affects biological activity. | 2006 Aug 28 |
1 |
| 16 |
15649641 | Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes. | 2005 Mar |
1 |
| 17 |
15766918 | Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2. | 2005 Feb 28 |
4 |
| 18 |
15276085 | Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. | 2004 Aug 15 |
1 |
| 19 |
15279827 | Identification of cytochrome P-450s involved in the formation of APNH from norharman with aniline. | 2004 Aug 8 |
1 |
| 20 |
15537169 | The in vitro metabolism of desglymidodrine, an active metabolite of prodrug midodrine by human liver microsomes. | 2004 Jul-Sep |
1 |
| 21 |
15696928 | [Mechanism of mono-hydroxylation of daidzein in human liver microsomes]. | 2004 Nov |
2 |
| 22 |
12495659 | The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line. | 2003 Jan |
1 |
| 23 |
12569440 | Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. | 2003 |
1 |
| 24 |
12721102 | Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine. | 2003 Apr |
1 |
| 25 |
12867277 | Evidence for the involvement of human liver microsomes CYP1A2 in the mono-hydroxylation of daidzein. | 2003 Aug |
2 |
| 26 |
11744615 | CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation. | 2002 Jan |
1 |
| 27 |
12180536 | The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. | 2002 Jul |
1 |
| 28 |
12523495 | Perazine as a potent inhibitor of human CYP1A2 but not CYP3A4. | 2002 Jul-Aug |
1 |
| 29 |
15618695 | Application of microtiter plate assay to evaluate inhibitory effects of various compounds on nine cytochrome P450 isoforms and to estimate their inhibition patterns. | 2002 |
1 |
| 30 |
11231111 | High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction--tandem mass spectrometry method for CYP1A2 inhibition assessment. | 2001 Feb |
1 |
| 31 |
10727902 | Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons. | 2000 Mar 23 |
1 |
| 32 |
10992045 | A fluorescent cell-based assay for cytochrome P-450 isozyme 1A2 induction and inhibition. | 2000 Aug |
1 |
| 33 |
11095582 | Identification of the human liver cytochrome P450 isoenzyme responsible for the 6-methylhydroxylation of the novel anticancer drug 5,6-dimethylxanthenone-4-acetic acid. | 2000 Dec |
2 |
| 34 |
11315102 | Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1. | 2000 Oct |
1 |
| 35 |
11315104 | Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms. | 2000 Oct |
1 |
| 36 |
11790342 | Catalytic properties of CYP1A isoforms in the liver of an agnathan (Lampetra fluviatilis) and two species of teleost (Pleuronectes flesus, Anguilla anguilla). | 2000 Feb |
1 |
| 37 |
10078840 | Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential. | 1999 Jan |
1 |
| 38 |
10215755 | Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism. | 1999 Mar |
1 |
| 39 |
10359460 | Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine. | 1999 Apr 1 |
1 |
| 40 |
10418968 | Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. | 1999 Jun 1 |
1 |
| 41 |
10460803 | Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. | 1999 Sep |
1 |
| 42 |
10553725 | Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. | 1999 Aug |
1 |
| 43 |
9435160 | Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. | 1998 Jan |
1 |
| 44 |
9491822 | Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. | 1998 Feb |
1 |
| 45 |
9585555 | Mechanism-based inactivation of human cytochrome P450 1A2 by furafylline: detection of a 1:1 adduct to protein and evidence for the formation of a novel imidazomethide intermediate. | 1998 May 19 |
4 |
| 46 |
9825830 | In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol. | 1998 Oct |
1 |
| 47 |
9884161 | Respective roles of human cytochrome P-4502E1, 1A2, and 3A4 in the hepatic microsomal ethanol oxidizing system. | 1998 Dec |
1 |
| 48 |
9202738 | Assessing human risk to heterocyclic amines. | 1997 May 12 |
1 |
| 49 |
9351903 | Formation of guanoxabenz from guanabenz in human liver. A new metabolic marker for CYP1A2. | 1997 Nov |
1 |
| 50 |
9394024 | Cytochrome P450 isozymes involved in lisofylline metabolism to pentoxifylline in human liver microsomes. | 1997 Dec |
1 |