Ketoconazole

cytochrome P450 family 1 subfamily A member 2 ; Homo sapiens







18 Article(s)
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1 29155491 Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors. 2018 Apr 1
2 25159194 Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects. 2015 Feb 1
3 23001793 Stereoselective interaction between tetrahydropalmatine enantiomers and CYP enzymes in human liver microsomes. 2013 Jan 1
4 23434495 Identification of cytochrome P450 isoenzymes involved in metabolism of (+)-praeruptorin A, a calcium channel blocker, by human liver microsomes using ultra high-performance liquid chromatography coupled with tandem mass spectrometry. 2013 Apr 15 1
5 22022918 Ilaprazole, a new proton pump inhibitor, is primarily metabolized to ilaprazole sulfone by CYP3A4 and 3A5. 2012 Mar 1
6 22266842 Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. 2012 Apr 1
7 21277363 Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes. 2011 Apr 10 1
8 18950609 Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1. 2009 Apr 15 1
9 19843060 In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation. 2009 Oct 1
10 18819885 [Effect of ketoconazole on the activity of CYP4503A4 and CYP450 1A2 of hepatic microsomes in healthy adults]. 2008 Aug 3
11 17542019 In vitro assessment of cytochrome P450 inhibition: strategies for increasing LC/MS-based assay throughput using a one-point IC(50) method and multiplexing high-performance liquid chromatography. 2007 Sep 1
12 15618748 In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole. 2003 1
13 9925971 In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes. 1999 Mar 1
14 10078840 Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential. 1999 Jan 1
15 10418968 Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential. 1999 Jun 1 1
16 9531525 Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor. 1998 Apr 1
17 9384460 The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine. 1997 Nov 1
18 8591723 Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans. 1995 Nov 1