Acetaminophen

cytochrome P450 family 1 subfamily A member 2 ; Homo sapiens







26 Article(s)
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Pub. Year
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1 35500453 Short-term high-fat diet alters acetaminophen metabolism in healthy individuals. 2022 Apr 30 1
2 31393259 Granzyme B and miR-378a Interaction in Acetaminophen Toxicity in Children. 2020 2
3 31706005 HepG2-1A2 C2 and C7: Lentivirus vector-mediated stable and functional overexpression of cytochrome P450 1A2 in human hepatoblastoma cells. 2020 Feb 1 1
4 28951593 MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity. 2017 Sep 26 2
5 28963035 miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 Expression. 2017 Dec 1
6 24119207 Possibility of decrease in CYP1A2 function in patients with end-stage renal disease. 2014 Apr 1
7 24498291 Understanding a substrate's product regioselectivity in a family of enzymes: a case study of acetaminophen binding in cytochrome P450s. 2014 1
8 24732412 Potential drug interactions with melatonin. 2014 May 28 2
9 22305191 Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes. 2012 Mar 15 1
10 22949628 Preferred binding orientations of phenacetin in CYP1A1 and CYP1A2 are associated with isoform-selective metabolism. 2012 Dec 1
11 21111054 Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2. 2011 May-Jun 1
12 21825116 Effect of dimethyl sulfoxide on in vitro cytochrome P4501A2 mediated phenacetin O-deethylation in human liver microsomes. 2011 Nov 1
13 19219744 Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes. 2009 Jan 1
14 18588957 Prevention of acetaminophen (APAP)-induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine. 2008 Aug 28 1
15 23045133 Measurement of human cytochrome P4501A2 (CYP1A2) activity in vitro. 2006 1
16 10811468 The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy. 2000 Apr 2
17 11130219 Enzymatic shunting: resolving the acetaminophen-warfarin controversy. 2000 Dec 4
18 9867310 In vivo age-related changes in hepatic drug-oxidizing capacity in humans. 1998 Aug 1
19 9110357 Lifestyle and nutritional correlates of cytochrome CYP1A2 activity: inverse associations with plasma lutein and alpha-tocopherol. 1997 Feb 2
20 9246016 The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin. 1997 Jul 2
21 8861779 Paracetamol-induced spindle disturbances in V79 cells with and without expression of human CYP1A2. 1996 Apr 2
22 8986010 Phenacetin O-deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine. 1996 Dec 1
23 8563766 Role of cytochrome P4501A2 in chemical carcinogenesis: implications for human variability in expression and enzyme activity. 1995 Oct 1
24 7987405 The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes. 1994 Aug 1
25 8261468 CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans. 1994 Jan 1 1
26 2351129 Influence of some anti-inflammatory drugs on the activity of aryl hydrocarbon hydroxylase and the cytochrome P450 content. 1990 Jun 1