Fluvoxamine

cytochrome P450 family 1 subfamily A member 2 ; Homo sapiens







106 Article(s)
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1 35362343 Fluvoxamine used to treat COVID-19 resulting in theophylline toxicity from CYP 1A2 drug-drug interaction. 2022 Apr 1 1
2 34564289 Selective Serotonin Reuptake Inhibitors and Clozapine: Clinically Relevant Interactions and Considerations. 2021 Sep 1 1
3 33302490 A Physiologically-Based Pharmacokinetic (PBPK) Model Network for the Prediction of CYP1A2 and CYP2C19 Drug-Drug-Gene Interactions with Fluvoxamine, Omeprazole, S-mephenytoin, Moclobemide, Tizanidine, Mexiletine, Ethinylestradiol, and Caffeine. 2020 Dec 8 1
4 30762305 Physiologically-Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam. 2019 May 1
5 31172535 Drug-Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC-122) in Healthy Adult Subjects. 2019 Dec 1
6 31182321 Effect of fluvoxamine augmentation and smoking on clozapine serum concentrations. 2019 Aug 1
7 29101463 A drug-drug interaction study to assess the effect of the CYP1A2 inhibitor fluvoxamine on the pharmacokinetics of dovitinib (TKI258) in patients with advanced solid tumors. 2018 Jan 1
8 29155491 Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2- and CYP3A4-selective Inhibitors. 2018 Apr 2
9 27821711 Low Potential of Basimglurant to Be Involved in Drug-Drug Interactions: Influence of Non-Michaelis-Menten P450 Kinetics on Fraction Metabolized. 2017 Jan 2
10 26626327 The clinical potentials of adjunctive fluvoxamine to clozapine treatment: a systematic review. 2016 Mar 1
11 26886336 Dynamic and Static Simulations of Fluvoxamine-Perpetrated Drug-Drug Interactions Using Multiple Cytochrome P450 Inhibition Modeling, and Determination of Perpetrator-Specific CYP Isoform Inhibition Constants and Fractional CYP Isoform Contributions to Victim Clearance. 2016 Mar 1
12 25159194 Pomalidomide: evaluation of cytochrome P450 and transporter-mediated drug-drug interaction potential in vitro and in healthy subjects. 2015 Feb 1
13 25719307 Pharmacogenetics of drug oxidation via cytochrome P450 (CYP) in the populations of Denmark, Faroe Islands and Greenland. 2015 Sep 1
14 26099559 Simulation of Metabolic Drug-Drug Interactions Perpetrated by Fluvoxamine Using Hybridized Two-Compartment Hepatic Drug-Pool-Based Tube Modeling and Estimation of In Vivo Inhibition Constants. 2015 Oct 2
15 24793403 Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism. 2014 Jun 1
16 24846087 Clozapine-associated development of second-onset obsessive compulsive symptoms in schizophrenia: impact of clozapine serum levels and fluvoxamine add-on. 2014 May 1
17 23001793 Stereoselective interaction between tetrahydropalmatine enantiomers and CYP enzymes in human liver microsomes. 2013 Jan 2
18 21277363 Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes. 2011 Apr 10 1
19 21979923 Augmentative effects of fluvoxamine on duloxetine plasma levels in depressed patients. 2011 Nov 2
20 20435083 Cytochromes P4501 (CYP1): catalytic activities and inducibility by diesel exhaust particle extract and benzo[a]pyrene in intact human lung ex vivo. 2010 Jun 29 1
21 19225771 Effect of smoking and CYP2D6 polymorphisms on the extent of fluvoxamine-alprazolam interaction in patients with psychosomatic disease. 2009 Jul 2
22 19593168 ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine. 2009 Aug 1
23 19843060 In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation. 2009 Oct 1
24 18438654 The effect of fluvoxamine on the pharmacokinetics, safety, and tolerability of ramosetron in healthy subjects. 2008 Jul 1
25 18690879 Enzyme inhibition and induction in liver disease. 2008 Jan 1
26 18691982 Clinically relevant pharmacokinetic drug interactions with second-generation antidepressants: an update. 2008 Jul 1
27 18816299 In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. 2008 Aug 1
28 17166674 Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes. 2007 Jan 30 3
29 17214606 Metabolic drug interactions with newer antipsychotics: a comparative review. 2007 Jan 1
30 17504220 CYP-mediated clozapine interactions: how predictable are they? 2007 May 1
31 17596106 Effect of fluvoxamine on the pharmacokinetics of roflumilast and roflumilast N-oxide. 2007 3
32 17823102 Drug interactions with smoking. 2007 Sep 15 1
33 16678550 Liver dysfunction markedly decreases the inhibition of cytochrome P450 1A2-mediated theophylline metabolism by fluvoxamine. 2006 May 4
34 16893613 Co-administration of ramelton and fluvoxamine to increase levels of interleukin-2. 2006 2
35 16918719 Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine. 2006 Aug 2
36 16985100 Rofecoxib is a potent, metabolism-dependent inhibitor of CYP1A2: implications for in vitro prediction of drug interactions. 2006 Dec 1
37 17045169 Metabolism of the A1 adenosine receptor PET ligand [18F]CPFPX by CYP1A2: implications for bolus/infusion PET studies. 2006 Oct 1
38 15738749 Low-dose fluvoxamine as an adjunct to reduce olanzapine therapeutic dose requirements: a prospective dose-adjusted drug interaction strategy. 2005 Apr 2
39 15845683 The effect of erythromycin and fluvoxamine on the pharmacokinetics of intravenous lidocaine. 2005 May 2
40 16236038 Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics. 2005 Nov 2
41 14749694 Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function. 2004 Jan 1
42 15060511 Fluvoxamine drastically increases concentrations and effects of tizanidine: a potentially hazardous interaction. 2004 Apr 1
43 15199661 Some aspects of genetic polymorphism in the biotransformation of antidepressants. 2004 Jan-Feb 1
44 15545309 Dose-dependent alternations in the pharmacokinetics of olanzapine during coadministration of fluvoxamine in patients with schizophrenia. 2004 Dec 1
45 12695344 Comparison of in vitro and in vivo inhibition potencies of fluvoxamine toward CYP2C19. 2003 May 1
46 12828569 In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s. 2003 Jul 1
47 14703714 Metabolic drug interactions with new psychotropic agents. 2003 Oct 1
48 11803239 Interaction between fluvoxamine and cotinine or caffeine. 2002 1
49 11876575 Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: an update. 2002 Feb 1
50 11907488 Low daily 10-mg and 20-mg doses of fluvoxamine inhibit the metabolism of both caffeine (cytochrome P4501A2) and omeprazole (cytochrome P4502C19). 2002 Mar 5