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33446483 | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. | 2021 Mar 5 |
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30563842 | Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by degrading Gag via activity of the ubiquitin ligase TRC8. | 2019 Feb 8 |
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26160948 | PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels. | 2015 Jul 10 |
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24860107 | Sequential actions of the AAA-ATPase valosin-containing protein (VCP)/p97 and the proteasome 19 S regulatory particle in sterol-accelerated, endoplasmic reticulum (ER)-associated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. | 2014 Jul 4 |
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23403031 | Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells. | 2013 Apr |
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24025715 | Sterol-induced dislocation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from membranes of permeabilized cells. | 2013 Nov |
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22143767 | Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8. | 2011 Dec 20 |
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20482385 | Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. | 2010 Jun |
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19458199 | Dislocation of HMG-CoA reductase and Insig-1, two polytopic endoplasmic reticulum proteins, en route to proteasomal degradation. | 2009 Jul |
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19638338 | Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells. | 2009 Sep 25 |
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19815544 | Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes. | 2009 Dec 11 |
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18504457 | Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. | 2008 Jun |
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18835813 | Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step. | 2008 Nov 28 |
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16399501 | Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake. | 2006 Jan |
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16549805 | Proteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysines. | 2006 Mar 28 |
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16606821 | Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis. | 2006 Apr 18 |
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17043353 | Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78. | 2006 Dec 22 |
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15899885 | Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. | 2005 Jul 15 |
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14660594 | Membrane topology of human insig-1, a protein regulator of lipid synthesis. | 2004 Feb 27 |
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15304479 | Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1. | 2004 Oct 22 |
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| 21 |
12535518 | Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. | 2003 Jan |
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12842885 | Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs. | 2003 Sep 12 |
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12963821 | Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles. | 2003 Sep 16 |
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14563840 | Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. | 2003 Dec 26 |
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| 25 |
14587295 | Control of lipid metabolism by regulated intramembrane proteolysis of sterol regulatory element binding proteins (SREBPs). | 2003 |
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12202038 | Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. | 2002 Aug 23 |
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12242332 | Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. | 2002 Oct 1 |
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12242342 | The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP. | 2002 Oct 1 |
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