Phosphatidylinositol 4,5-Diphosphate

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 ; Homo sapiens







29 Article(s)
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1 34928298 The versatile regulation of K2P channels by polyanionic lipids of the phosphoinositide and fatty acid metabolism. 2022 Feb 7 1
2 34447786 Simulating PIP2-Induced Gating Transitions in Kir6.2 Channels. 2021 4
3 32213593 Defining how multiple lipid species interact with inward rectifier potassium (Kir2) channels. 2020 Apr 7 3
4 29317494 Hydrogen sulfide inhibits Kir2 and Kir3 channels by decreasing sensitivity to the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2). 2018 Mar 9 3
5 28446610 Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating. 2017 Jun 16 1
6 29192147 Protein crowding and lipid complexity influence the nanoscale dynamic organization of ion channels in cell membranes. 2017 Nov 30 3
7 26837888 The ICl,swell inhibitor DCPIB blocks Kir channels that possess weak affinity for PIP2. 2016 May 4
8 26063437 Identification of the Conformational transition pathway in PIP2 Opening Kir Channels. 2015 Jun 11 3
9 23270460 Simulation-based prediction of phosphatidylinositol 4,5-bisphosphate binding to an ion channel. 2013 Jan 15 1
10 23448372 Inhibition of cardiac inward rectifier currents by cationic amphiphilic drugs. 2013 Sep 1
11 24270915 Secondary anionic phospholipid binding site and gating mechanism in Kir2.1 inward rectifier channels. 2013 2
12 22995912 Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)). 2012 Nov 23 2
13 21779761 Mechanisms for Kir channel inhibition by quinacrine: acute pore block of Kir2.x channels and interference in PIP2 interaction with Kir2.x and Kir6.2 channels. 2011 Oct 2
14 20921230 Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate. 2010 Nov 26 2
15 20937804 Gating of a G protein-sensitive mammalian Kir3.1 prokaryotic Kir channel chimera in planar lipid bilayers. 2010 Dec 17 1
16 21150302 Lipids driving protein structure? Evolutionary adaptations in Kir channels. 2010 May-Jun 1
17 19641096 Regulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate. 2009 Oct 4
18 19839652 PIP(2)-binding site in Kir channels: definition by multiscale biomolecular simulations. 2009 Nov 24 5
19 18690051 Stoichiometry of Kir channels with phosphatidylinositol bisphosphate. 2008 Jan-Feb 2
20 16837026 Activation of inwardly rectifying potassium (Kir) channels by phosphatidylinosital-4,5-bisphosphate (PIP2): interaction with other regulatory ligands. 2007 Jul 1
21 17495041 Diverse Kir modulators act in close proximity to residues implicated in phosphoinositide binding. 2007 Aug 1 1
22 17698006 PIP2--the master key. 2007 Aug 16 2
23 17698013 H bonding at the helix-bundle crossing controls gating in Kir potassium channels. 2007 Aug 16 1
24 16144841 Direct modulation of Kir channel gating by membrane phosphatidylinositol 4,5-bisphosphate. 2005 Oct 28 2
25 16316973 Long polyamines act as cofactors in PIP2 activation of inward rectifier potassium (Kir2.1) channels. 2005 Dec 2
26 15155739 Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators. 2004 Sep 3 3
27 12086641 Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. 2002 Jun 13 2
28 10871638 Biophysical and molecular mechanisms underlying the modulation of heteromeric Kir4.1-Kir5.1 channels by CO2 and pH. 2000 Jul 1 3
29 10593888 Distinct specificities of inwardly rectifying K(+) channels for phosphoinositides. 1999 Dec 17 1