Zinc

amyloid beta precursor protein ; Homo sapiens







136 Article(s)
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51 24698848 Metal-dependent amyloid β-degrading catalytic antibody construct. 2014 Jun 20 1
52 24871565 Metal ions and intrinsically disordered proteins and peptides: from Cu/Zn amyloid-β to general principles. 2014 Aug 19 7
53 25137638 Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: correlation dynamics and zinc binding. 2014 Dec 4
54 25536033 Amyloid β-mediated Zn2+ influx into dentate granule cells transiently induces a short-term cognitive deficit. 2014 9
55 23276205 Surface plasmon resonance imaging of amyloid-β aggregation kinetics in the presence of epigallocatechin gallate and metals. 2013 Feb 19 2
56 23609990 Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide. 2013 Oct 1
57 23660814 Molecular dynamics simulation and molecular docking studies of Angiotensin converting enzyme with inhibitor lisinopril and amyloid Beta Peptide. 2013 Jun 1
58 23947440 Effects of Zn2+ binding on the structural and dynamic properties of amyloid β peptide associated with Alzheimer's disease: Asp1 or Glu11? 2013 Nov 20 3
59 23983094 Biophysical studies of the amyloid β-peptide: interactions with metal ions and small molecules. 2013 Sep 23 1
60 24037720 Characterization of the polymorphic states of copper(II)-bound Aβ(1-16) peptides by computational simulations. 2013 Nov 5 1
61 22138653 Zinc-mediated modulation of the configuration and activity of complexes between copper and amyloid-β peptides. 2012 Jan 6 2
62 22318122 Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease. 2012 Mar 1
63 22349685 Zinc transporter mRNA levels in Alzheimer's disease postmortem brain. 2012 2
64 22366383 Metal-associated amyloid-β species in Alzheimer's disease. 2012 Apr 2
65 22423218 All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers. 2012 Mar 13 2
66 22452395 Bifunctional compounds for controlling metal-mediated aggregation of the aβ42 peptide. 2012 Apr 18 2
67 22558227 Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies. 2012 2
68 22829296 Combining conformational sampling and selection to identify the binding mode of zinc-bound amyloid peptides with bifunctional molecules. 2012 Aug 9
69 22832069 Structural basis behind the interaction of Zn²⁺ with the protein α-synuclein and the Aβ peptide: a comparative analysis. 2012 Dec 1
70 23062696 NMR metabolomic investigation of astrocytes interacted with Aβ₄₂ or its complexes with either copper(II) or zinc(II). 2012 Dec 1
71 21216965 Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation. 2011 Mar 18 4
72 21359283 Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity. 2011 Mar 1
73 21612223 Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of Aβ(1-16)-polyethylenglycol-ylated peptide: implications in Alzheimer's disease. 2011 Jun 20 3
74 21797865 The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity. 2011 Oct 5
75 21889458 Effect of zinc binding on β-amyloid structure and dynamics: implications for Aβ aggregation. 2011 Sep 7 1
76 21939532 Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold. 2011 Sep 22 8
77 22261072 Zn(++) binding disrupts the Asp(23)-Lys(28) salt bridge without altering the hairpin-shaped cross-β Structure of Aβ(42) amyloid aggregates. 2011 Dec 7 5
78 20152387 Gold nanoparticle-based colorimetric sensor for studying the interactions of beta-amyloid peptide with metallic ions. 2010 Mar 15 5
79 20448202 Zinc ions promote Alzheimer Abeta aggregation via population shift of polymorphic states. 2010 May 25 4
80 20640797 On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study. 2010 Mar 1
81 20942746 Novel drug targets based on metallobiology of Alzheimer's disease. 2010 Nov 2
82 21197068 Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease. 2010 Dec 8 2
83 19037857 Insights into the mechanism of methionine oxidation catalyzed by metal (Cu(2+), Zn(2+), and Fe(3+)) - amyloid beta (Abeta) peptide complexes: A computational study. 2009 Jul 15 2
84 19083027 Mechanism of zinc(II)-promoted amyloid formation: zinc(II) binding facilitates the transition from the partially alpha-helical conformer to aggregates of amyloid beta protein(1-28). 2009 Mar 2
85 19141082 Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation. 2009 Mar 5
86 19322475 Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide. 2009 Feb 21 1
87 19352532 Glycosylated tetrahydrosalens as multifunctional molecules for Alzheimer's therapy. 2009 Apr 28 3
88 19409221 Distribution and progression of amyloid-beta deposits in the amygdala of the aged macaque monkey, and parallels with zinc distribution. 2009 Apr 10 1
89 19485411 Site-activated multifunctional chelator with acetylcholinesterase and neuroprotective-neurorestorative moieties for Alzheimer's therapy. 2009 Jul 23 1
90 19549187 Quenched hydrogen/deuterium exchange NMR characterization of amyloid-beta peptide aggregates formed in the presence of Cu2+ or Zn2+. 2009 Aug 3
91 19731816 [Therapy of Alzheimer disease]. 2009 Mar 1
92 19780525 Metal loading capacity of Abeta N-terminus: a combined potentiometric and spectroscopic study of zinc(II) complexes with Abeta(1-16), its short or mutated peptide fragments and its polyethylene glycol-ylated analogue. 2009 Nov 2 6
93 19809679 Modeling of the Zn2+ binding in the 1-16 region of the amyloid beta peptide involved in Alzheimer's disease. 2009 Aug 14 1
94 19877000 Copper and zinc binding to amyloid-beta: coordination, dynamics, aggregation, reactivity and metal-ion transfer. 2009 Dec 14 7
95 18289347 Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide. 2008 Mar 6
96 18570397 Mechanistic studies of Cu(II) binding to amyloid-beta peptides and the fluorescence and redox behaviors of the resulting complexes. 2008 Jul 17 1
97 18598056 Soluble amyloid beta1-28-copper(I)/copper(II)/Iron(II) complexes are potent antioxidants in cell-free systems. 2008 Jul 29 1
98 18712494 Mutual stimulation of beta-amyloid fibrillogenesis by clioquinol and divalent metals. 2008 2
99 17028131 Time-dependent DNA condensation induced by amyloid beta-peptide. 2007 Jan 1 1
100 17511455 Synthesis, characterization, and metal coordinating ability of multifunctional carbohydrate-containing compounds for Alzheimer's therapy. 2007 Jun 13 2