Zinc

amyloid beta precursor protein ; Homo sapiens







136 Article(s)
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1 34793899 Isoproterenol injected into the basolateral amygdala rescues amyloid β1-42-induced conditioned fear memory deficit via reducing intracellular Zn2+ toxicity. 2022 Jan 1 2
2 35064350 Isoproterenol, an adrenergic β receptor agonist, induces metallothionein synthesis followed by canceling amyloid β1-42-induced neurodegeneration. 2022 Apr 1
3 35101650 Synthesis, biological evaluation, and molecular modeling simulations of new heterocyclic hybrids as multi-targeted anti-Alzheimer's agents. 2022 Mar 5 1
4 33400522 Unexpected Trends in Copper Removal from Aβ Peptide: When Less Ligand Is Better and Zn Helps. 2021 Jan 18 1
5 33758258 The nickel-chelator dimethylglyoxime inhibits human amyloid beta peptide in vitro aggregation. 2021 Mar 23 1
6 33909969 Lithium ions display weak interaction with amyloid-beta (Aβ) peptides and have minor effects on their aggregation. 2021 Apr 28 1
7 34162214 Multifunctional Redox Modulators Protect Auditory, Visual, and Cognitive Function. 2021 Aug 13 3
8 34343891 Structural significance of Neprylysin from Streptococcus suis GZ1 in the degradation of Aβ peptides, a causative agent in Alzheimer's disease. 2021 Sep 3
9 34817990 Time-Evolved SERS Signatures of DEP-Trapped Aβ and Zn2+Aβ Peptides Revealed by a Sub-10 nm Electrode Nanogap. 2021 Dec 14 1
10 34831318 Multi-Target Effects of Novel Synthetic Coumarin Derivatives Protecting Aβ-GFP SH-SY5Y Cells against Aβ Toxicity. 2021 Nov 9 1
11 34988394 Amyloid-beta-copper interaction studied by simultaneous nitrogen K and copper L2,3 -edge soft X-ray absorption spectroscopy. 2021 Dec 17 2
12 31272355 Zinc-mediated Neurotransmission in Alzheimer's Disease: A Potential Role of the GPR39 in Dementia. 2020 2
13 31786439 Modified EDTA selectively recognized Cu2+ and its application in the disaggregation of β-amyloid-Cu (II)/Zn (II) aggregates. 2020 Feb 1
14 31820684 Inhibition of Amyloid β Aggregation Using Optimized Nano-Encapsulated Formulations of Plant Extracts with High Metal Chelator Activities. 2020 2
15 32297620 Peroxidase activity of heme bound amyloid β peptides associated with Alzheimer's disease. 2020 Apr 28 1
16 32518388 Alzheimer risk factors age and female sex induce cortical Aβ aggregation by raising extracellular zinc. 2020 Nov 1
17 32630615 Rationally Designed Antibodies as Research Tools to Study the Structure-Toxicity Relationship of Amyloid-β Oligomers. 2020 Jun 25 1
18 33081348 Copper Toxicity Links to Pathogenesis of Alzheimer's Disease and Therapeutics Approaches. 2020 Oct 16 1
19 33137558 Inhibition of Aβ aggregates in Alzheimer's disease by epigallocatechin and epicatechin-3-gallate from green tea. 2020 Dec 2
20 30234208 Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers. 2019 Jan 23 8
21 30501186 Dual-Aptamer-Conjugated Molecular Modulator for Detecting Bioactive Metal Ions and Inhibiting Metal-Mediated Protein Aggregation. 2019 Jan 2 5
22 30843389 Ferrocene-Encapsulated Zn Zeolitic Imidazole Framework (ZIF-8) for Optical and Electrochemical Sensing of Amyloid-β Oligomers and for the Early Diagnosis of Alzheimer's Disease. 2019 Mar 27 1
23 31042246 Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)-amyloid-β. 2019 May 21 2
24 31140779 Small Molecule Inhibits Metal-Dependent and -Independent Multifaceted Toxicity of Alzheimer's Disease. 2019 Aug 21 1
25 31247877 Copper-Targeting Approaches in Alzheimer's Disease: How To Improve the Fallouts Obtained from in Vitro Studies. 2019 Oct 21 2
26 31326861 A simple approach to quantitative determination of soluble amyloid-β peptides using a ratiometric fluorescence probe. 2019 Oct 1 8
27 31370315 Zn2+ Interaction with Amyloid-Β: Affinity and Speciation. 2019 Jul 31 2
28 29555950 Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer's disease. 2018 Mar 19 3
29 29957993 Copper Binding Induces Polymorphism in Amyloid-β Peptide: Results of Computational Models. 2018 Jul 26 1
30 30213975 Copper mediated amyloid-β binding to Transthyretin. 2018 Sep 13 1
31 28096459 Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production. 2017 Mar 3 4
32 28209516 Movement of the β-hairpin in the third zinc-binding module of UvrA is required for DNA damage recognition. 2017 Mar 1
33 28378589 Kinetic Insights into Zn2+-Induced Amyloid β-Protein Aggregation Revealed by Stopped-Flow Fluorescence Spectroscopy. 2017 Apr 27 4
34 28621929 Kinetic Analysis Reveals the Identity of Aβ-Metal Complex Responsible for the Initial Aggregation of Aβ in the Synapse. 2017 Sep 20 5
35 28972932 Brazilin inhibits the Zn2+-mediated aggregation of amyloid β-protein and alleviates cytotoxicity. 2017 Dec 1
36 27121137 High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer's disease. 2016 Apr 28 1
37 27501363 Amyloid β attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca2+ , ERK1/2 and Clusterin signaling in neurons. 2016 Oct 8
38 27567855 Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species. 2016 Oct 4 2
39 27665863 Zinc(II) Binding Site to the Amyloid-β Peptide: Insights from Spectroscopic Studies with a Wide Series of Modified Peptides. 2016 Oct 17 3
40 27711738 How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study. 2016 Oct 4 3
41 25227315 Effects of multifunctional antioxidants on mitochondrial dysfunction and amyloid-β metal dyshomeostasis. 2015 4
42 25366568 Single-cell screening of cytosolic [Ca(2+)] reveals cell-selective action by the Alzheimer's Aβ peptide ion channel. 2015 Mar 1
43 25597800 Development of gold nanoparticle based colorimetric method for quantitatively studying the inhibitors of Cu(2+)/Zn(2+) induced β-amyloid peptide assembly. 2015 Feb 9 3
44 25818846 Regulation of extracellular Zn(2+) homeostasis in the hippocampus as a therapeutic target for Alzheimer's disease. 2015 5
45 25825723 Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation. 2015 Apr 28 1
46 25959547 Is interaction of amyloid β-peptides with metals involved in cognitive activity? 2015 Aug 6
47 25968625 Two macrocyclic polyamines as modulators of metal-mediated Aβ40 aggregation. 2015 Jun 2
48 24195102 LED-based interferometric reflectance imaging sensor for the detection of amyloid-β aggregation. 2014 Jan 7 2
49 24326305 A small molecule that displays marked reactivity toward copper- versus zinc-amyloid-β implicated in Alzheimer's disease. 2014 May 25 1
50 24456271 Metallothioneins and synthetic metal chelators as potential therapeutic agents for removal of aberrant metal ions from metal-Aβ species. 2014 1