Folic Acid

solute carrier family 19 member 1 ; Homo sapiens







97 Article(s)
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1 35157101 Evaluation of cytogenetic and molecular markers with MTX-mediated toxicity in pediatric acute lymphoblastic leukemia patients. 2022 Mar 1
2 35303537 Structural basis for recognition and transport of folic acid in mammalian cells. 2022 Jun 2
3 32820034 CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression. 2021 Jul 2
4 33326752 Tumor Reliance on Cytosolic versus Mitochondrial One-Carbon Flux Depends on Folate Availability. 2021 Jan 5 2
5 33933170 The transcriptome profile of human trisomy 21 blood cells. 2021 May 1 1
6 34769063 Targeting Folate Metabolism Is Selectively Cytotoxic to Glioma Stem Cells and Effectively Cooperates with Differentiation Therapy to Eliminate Tumor-Initiating Cells in Glioma Xenografts. 2021 Oct 27 3
7 32276275 A homozygous deletion in the SLC19A1 gene as a cause of folate-dependent recurrent megaloblastic anemia. 2020 Jun 25 1
8 32403197 Methylation analysis of the SLC19A1 promoter region in Chinese children with acute lymphoblastic leukaemia. 2020 Aug 2
9 33164984 Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo. 2020 Dec 1 1
10 30324648 Reduced folate carrier-mediated methotrexate transport in human distal lung epithelial NCl-H441 cells. 2019 Feb 5
11 30996094 Reduced Folate Carrier: an Entry Receptor for a Novel Feline Leukemia Virus Variant. 2019 Jul 1 1
12 31167838 Clinical Extrapolation of the Effects of Dolutegravir and Other HIV Integrase Inhibitors on Folate Transport Pathways. 2019 Aug 1
13 31223065 Folate pathway genes linked to mitochondrial biogenesis and respiration are associated with outcome of patients with stage III colorectal cancer. 2019 Jun 1
14 31511694 SLC19A1 transports immunoreactive cyclic dinucleotides. 2019 Sep 1
15 29121255 Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance. 2018 Feb 1 1
16 29345051 MiR-595 Suppresses the Cellular Uptake and Cytotoxic Effects of Methotrexate by Targeting SLC19A1 in CEM/C1 Cells. 2018 Jul 2
17 29986308 Down-regulation of placental folate transporters in intrauterine growth restriction. 2018 Sep 2
18 28885847 Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier. 2017 Nov 6 4
19 26561410 Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status. 2016 Jan 1
20 26959650 An Association Study of the SLC19A1 Gene Polymorphisms/Haplotypes with Idiopathic Recurrent Pregnancy Loss in an Iranian Population. 2016 May 1
21 27213354 A Study of Single Nucleotide Polymorphisms of the SLC19A1/RFC1 Gene in Subjects with Autism Spectrum Disorder. 2016 May 19 1
22 27547186 Genetic Polymorphisms Associated to Folate Transport as Predictors of Increased Risk for Acute Lymphoblastic Leukemia in Mexican Children. 2016 1
23 25841994 Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha. 2015 Jul 2
24 25860940 MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma. 2015 Jun 20 1
25 23912258 Reduced folate carrier (RFC) as a predictive marker for response to pemetrexed in advanced non-small cell lung cancer (NSCLC). 2014 Apr 1
26 24237708 The effect of RFC G80A polymorphism in Cretan children with acute lymphoblastic leukemia and its interaction with MTHFR C677T and A1298C polymorphisms. 2014 Aug 3
27 24771227 Reduced folate carrier-1 G80a gene polymorphism is associated with neuroblastoma's development. 2014 Aug 3
28 24949876 Post-transcriptional regulation of the human reduced folate carrier as a novel adaptive mechanism in response to folate excess or deficiency. 2014 Aug 6 4
29 24995314 A pilot study evaluating the contribution of SLC19A1 (RFC-1) 80G>a polymorphism to Alzheimer's disease in Italian Caucasians. 2014 1
30 23412628 Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter. 2013 Apr 1
31 23449276 Reduced folate carrier and folylpolyglutamate synthetase, but not thymidylate synthase predict survival in pemetrexed-treated patients suffering from malignant pleural mesothelioma. 2013 May 2
32 23506878 Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors. 2013 Apr-Jun 1
33 23599757 Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy. 2013 Apr 1
34 23857226 The reduced folate carrier (RFC-1) 80A>G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis. 2013 Jul 5 1
35 22377700 Maternal risk for Down syndrome is modulated by genes involved in folate metabolism. 2012 1
36 22894559 Reduced folate carrier independent internalization of PEGylated pemetrexed: a potential nanomedicinal approach for breast cancer therapy. 2012 Oct 1 2
37 21760912 Expression of RFC/SLC19A1 is associated with tumor type in bladder cancer patients. 2011 4
38 22039442 Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk. 2011 1
39 19841321 Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. 2010 Feb 1 1
40 20018840 Identification of the minimal functional unit of the homo-oligomeric human reduced folate carrier. 2010 Feb 12 3
41 20233025 The SLC19A1 80G>A polymorphism is not associated with male infertility. 2010 May 2
42 20890936 Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and/or palate in the Brazilian population. 2010 Nov 1
43 18414976 Mice transgenic for reduced folate carrier: an animal model of Down syndrome? 2009 Feb 1
44 19019821 Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function. 2009 Jan 30 3
45 19174154 Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs. 2009 Apr 1 1
46 19571232 Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier. 2009 Sep 3
47 19650776 The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women. 2009 Sep 6
48 19687280 Molecular cloning and tissue distribution of reduced folate carrier and effect of dietary folate supplementation on the expression of reduced folate carrier in laying hens. 2009 Sep 1
49 17983788 A humanized mouse model for the reduced folate carrier. 2008 Feb 3
50 18053808 Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels. 2008 Feb 3