| 1 |
34545025 | Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes. | 2022 Feb 1 |
2 |
| 2 |
35619086 | Role of human organic cation transporter-1 (OCT-1/SLC22A1) in modulating the response to metformin in patients with type 2 diabetes. | 2022 May 26 |
10 |
| 3 |
33967805 | Transport of Drugs and Endogenous Compounds Mediated by Human OCT1: Studies in Single- and Double-Transfected Cell Models. | 2021 |
3 |
| 4 |
34064886 | A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators. | 2021 May 11 |
2 |
| 5 |
34194474 | The Genetics of Adverse Drug Outcomes in Type 2 Diabetes: A Systematic Review. | 2021 |
3 |
| 6 |
34422646 | The Effects of NT-1044, a Novel AMPK Activator, on Endometrial Cancer Cell Proliferation, Apoptosis, Cell Stress and In Vivo Tumor Growth. | 2021 |
1 |
| 7 |
34665880 | Dorothy Hodgkin Lecture 2021: Drugs, genes and diabetes. | 2021 Dec |
1 |
| 8 |
31883148 | High affinity of 4-(4-(dimethylamino)styryl)-N-methylpyridinium transport for assessing organic cation drugs in hepatocellular carcinoma cells. | 2020 Jun |
1 |
| 9 |
31974043 | rs622342A>C in SLC22A1 is associated with metformin pharmacokinetics and glycemic response. | 2020 Feb |
3 |
| 10 |
32127372 | Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-Cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk. | 2020 May |
2 |
| 11 |
32407269 | Pharmacogenetic Evaluation of Metformin and Sulphonylurea Response in Mexican Mestizos with Type 2 Diabetes. | 2020 |
1 |
| 12 |
32454819 | SLC22A1 rs622342 Polymorphism Predicts Insulin Resistance Improvement in Patients with Type 2 Diabetes Mellitus Treated with Metformin: A Cross-Sectional Study. | 2020 |
4 |
| 13 |
32455555 | Pharmacokinetic Interaction between Metformin and Verapamil in Rats: Inhibition of the OCT2-Mediated Renal Excretion of Metformin by Verapamil. | 2020 May 21 |
2 |
| 14 |
32472157 | A drug-drug interaction study to evaluate the impact of peficitinib on OCT1- and MATE1-mediated transport of metformin in healthy volunteers. | 2020 Aug |
4 |
| 15 |
32551505 | A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker. | 2020 Jul 21 |
1 |
| 16 |
32575674 | rs622342 in SLC22A1, CYP2C9*2 and CYP2C9*3 and Glycemic Response in Individuals with Type 2 Diabetes Mellitus Receiving Metformin/Sulfonylurea Combination Therapy: 6-Month Follow-Up Study. | 2020 Jun 20 |
2 |
| 17 |
32606866 | Intronic Variants in OCT1 are Associated with All-Cause and Cardiovascular Mortality in Metformin Users with Type 2 Diabetes. | 2020 |
3 |
| 18 |
32843330 | Successful Prediction of Positron Emission Tomography-Imaged Metformin Hepatic Uptake Clearance in Humans Using the Quantitative Proteomics-Informed Relative Expression Factor Approach. | 2020 Nov |
2 |
| 19 |
33037045 | Differences in Metformin and Thiamine Uptake between Human and Mouse Organic Cation Transporter 1: Structural Determinants and Potential Consequences for Intrahepatic Concentrations. | 2020 Dec |
6 |
| 20 |
33533444 | Assessment of Interaction of Human OCT 1-3 Proteins and Metformin Using Silico Analyses. | 2020 Dec |
4 |
| 21 |
33658930 | Diffusion Mechanism Modeling of Metformin in Human Organic Cationic Amino Acid Transporter one and Functional Impact of S189L, R206C, and G401S Mutation. | 2020 |
3 |
| 22 |
30834005 | Allele Frequency of SLC22A1 Met420del Metformin Main Transporter Encoding Gene among Javanese-Indonesian Population. | 2019 Feb 15 |
4 |
| 23 |
30885951 | Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study. | 2019 Jun |
4 |
| 24 |
30934600 | Metformin Pharmacogenetics: Effects of SLC22A1, SLC22A2, and SLC22A3 Polymorphisms on Glycemic Control and HbA1c Levels. | 2019 Mar 25 |
2 |
| 25 |
30959948 | Association between Polymorphisms of OCT1 and Metabolic Response to Metformin in Women with Polycystic Ovary Syndrome. | 2019 Apr 7 |
6 |
| 26 |
30975793 | Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: "SLC-Phenotyping" Using Primary Human Hepatocytes. | 2019 Jul |
1 |
| 27 |
31012983 | Altered Glycemic Control Associated With Polymorphisms in the SLC22A1 (OCT1) Gene in a Mexican Population With Type 2 Diabetes Mellitus Treated With Metformin: A Cohort Study. | 2019 Oct |
5 |
| 28 |
31188026 | Pharmacogenetics of Metformin for Medication-Induced Weight Gain in Autism Spectrum Disorder. | 2019 Aug |
1 |
| 29 |
31231590 | The influence of SLC22A1 rs622342 and ABCC8 rs757110 genetic variants on the efficacy of metformin and glimepiride combination therapy in Egyptian patients with type 2 diabetes. | 2019 |
3 |
| 30 |
31427432 | Enhanced and Persistent Inhibition of Organic Cation Transporter 1 Activity by Preincubation of Cyclosporine A. | 2019 Nov |
4 |
| 31 |
31804919 | Probe Cocktail to Assess Transporter Function in Sandwich-Cultured Human Hepatocytes. | 2019 |
1 |
| 32 |
31886264 | Role of Metformin on Osteoblast Differentiation in Type 2 Diabetes. | 2019 |
1 |
| 33 |
28494141 | Metformin induces osteoblastic differentiation of human induced pluripotent stem cell-derived mesenchymal stem cells. | 2018 Feb |
2 |
| 34 |
29089306 | Organic Cation Transporter 1 Is Responsible for Hepatocellular Uptake of the Tyrosine Kinase Inhibitor Pazopanib. | 2018 Jan |
3 |
| 35 |
29193038 | Emerging Clinical Importance of Hepatic Organic Cation Transporter 1 (OCT1) in Drug Pharmacokinetics, Dynamics, Pharmacogenetic Variability, and Drug Interactions. | 2018 May |
2 |
| 36 |
29306537 | Metformin Enhances the Differentiation of Dental Pulp Cells into Odontoblasts by Activating AMPK Signaling. | 2018 Apr |
1 |
| 37 |
29352482 | Influence of pharmacogenetic polymorphisms and demographic variables on metformin pharmacokinetics in an admixed Brazilian cohort. | 2018 May |
2 |
| 38 |
29949790 | OCT1-Mediated Metformin Uptake Regulates Pancreatic Stellate Cell Activity. | 2018 |
8 |
| 39 |
29979413 | Genetic polymorphisms of organic cation transporter 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes: A systematic review. | 2018 Jul |
5 |
| 40 |
30041690 | Genetic polymorphisms of organic cation transporters 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes mellitus: a systematic review protocol. | 2018 Jul 25 |
5 |
| 41 |
30138624 | Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel. | 2018 Oct |
1 |
| 42 |
30191328 | Selective Inhibition on Organic Cation Transporters by Carvedilol Protects Mice from Cisplatin-Induced Nephrotoxicity. | 2018 Sep 6 |
1 |
| 43 |
30294927 | Co-administration of nuciferine reduces the concentration of metformin in liver via differential inhibition of hepatic drug transporter OCT1 and MATE1. | 2018 Nov |
2 |
| 44 |
30375241 | Metformin transporter pharmacogenomics: insights into drug disposition-where are we now? | 2018 Nov |
4 |
| 45 |
30544975 | Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1). | 2018 Dec 11 |
3 |
| 46 |
27407018 | Effects of SLC22A1 Polymorphisms on Metformin-Induced Reductions in Adiposity and Metformin Pharmacokinetics in Obese Children With Insulin Resistance. | 2017 Feb |
4 |
| 47 |
28380657 | Genetic Polymorphisms in Organic Cation Transporter 1 Attenuates Hepatic Metformin Exposure in Humans. | 2017 Nov |
4 |
| 48 |
28947922 | Diabetes medication associates with DNA methylation of metformin transporter genes in the human liver. | 2017 |
3 |
| 49 |
29236753 | Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine. | 2017 |
1 |
| 50 |
26605869 | Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes. | 2016 Apr |
6 |