Deoxycytidine

thymidine kinase 2 ; Homo sapiens







22 Article(s)
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1 35280287 Case Report: Thymidine Kinase 2 (TK2) Deficiency: A Novel Mutation Associated With Childhood-Onset Mitochondrial Myopathy and Atypical Progression. 2022 1
2 31060578 Late-onset thymidine kinase 2 deficiency: a review of 18 cases. 2019 May 6 1
3 29602790 Retrospective natural history of thymidine kinase 2 deficiency. 2018 Aug 2
4 31459030 Negative Cooperative Binding of Thymidine, Ordered Substrate Binding, and Product Release of Human Mitochondrial Thymidine Kinase 2 Explain Its Complex Kinetic Properties and Physiological Functions. 2018 Aug 31 5
5 26087398 siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine. 2015 Sep 8 2
6 25215937 Thymidine kinase 2 enzyme kinetics elucidate the mechanism of thymidine-induced mitochondrial DNA depletion. 2014 Oct 7 4
7 22074768 Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe. 2012 Jan 2 2
8 22571666 Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications. 2012 4
9 21444706 The kinetic effects on thymidine kinase 2 by enzyme-bound dTTP may explain the mitochondrial side effects of antiviral thymidine analogs. 2011 Jun 4
10 21491329 A mathematical model of human thymidine kinase 2 activity. 2011 Mar 5
11 20083405 Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion. 2010 Mar 1
12 18600552 5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts. 2008 Jun 1
13 17266931 Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2. 2007 Mar 16 1
14 14690426 Tight binding of deoxyribonucleotide triphosphates to human thymidine kinase 2 expressed in Escherichia coli. Purification and partial characterization of its dimeric and tetrameric forms. 2003 Dec 30 1
15 11687801 Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy. 2001 Nov 1
16 10606535 Stereoisomeric selectivity of human deoxyribonucleoside kinases. 1999 Dec 21 1
17 9461577 Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase. 1998 Feb 13 1
18 9079672 Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2. 1997 Mar 28 2
19 9359870 Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues. 1997 Nov 15 1
20 7637389 Increased ratio between deoxycytidine kinase and thymidine kinase 2 in CLL lymphocytes compared to normal lymphocytes. 1995 Jul 2
21 1359886 Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues. 1992 Oct 30 1
22 2026611 Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides. 1991 May 15 2