| 1 |
33290316 | A PI3K inhibitor-induced growth inhibition of cancer cells is linked to MEK-ERK pathway. | 2021 Jun 1 |
1 |
| 2 |
29959857 | Sp1 mediates phorbol ester (PMA)-induced expression of membrane-bound guanylyl cyclase GC-A in human monocytic THP-1 cells. | 2018 |
1 |
| 3 |
30073169 | LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion. | 2018 |
1 |
| 4 |
28286738 | TSC2/Rheb signaling mediates ERK-dependent regulation of mTORC1 activity in C2C12 myoblasts. | 2017 Mar |
2 |
| 5 |
26786102 | A Signaling Network Controlling Androgenic Repression of c-Fos Protein in Prostate Adenocarcinoma Cells. | 2016 Mar 11 |
1 |
| 6 |
25915860 | 12-O-Tetradecanoylphorbol-13-Acetate Induces Up-Regulated Transcription of Variant 1 but Not Variant 2 of VIL2 in Esophageal Squamous Cell Carcinoma Cells via ERK1/2/AP-1/Sp1 Signaling. | 2015 |
1 |
| 7 |
23175175 | Induction of differentiation-specific miRNAs in TPA-induced myeloid leukemia cells through MEK/ERK activation. | 2013 Jan |
3 |
| 8 |
23353996 | Silibinin inhibits TPA-induced cell migration and MMP-9 expression in thyroid and breast cancer cells. | 2013 Apr |
2 |
| 9 |
23775084 | The catalytic subunit of protein phosphatase 2A (PP2Ac) promotes DNA hypomethylation by suppressing the phosphorylated mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/phosphorylated ERK/DNMT1 protein pathway in T-cells from controls and systemic lupus erythematosus patients. | 2013 Jul 26 |
1 |
| 10 |
23786520 | Luteolin suppresses the differentiation of THP-1 cells through the Inhibition of NOX2 mRNA expression and the membrane translocation of p47phox. | 2013 Jul 26 |
2 |
| 11 |
23833248 | Defining the role of DAG, mitochondrial function, and lipid deposition in palmitate-induced proinflammatory signaling and its counter-modulation by palmitoleate. | 2013 Sep |
1 |
| 12 |
22020547 | TPA-induced p21 expression augments G2/M arrest through a p53-independent mechanism in human breast cancer cells. | 2012 Feb |
1 |
| 13 |
22052014 | PKCĪ“-dependent activation of ERK1/2 leads to upregulation of the human NHE2 transcriptional activity in intestinal epithelial cell line C2BBe1. | 2012 Feb 1 |
2 |
| 14 |
22313459 | TPA induces the expression of EC-SOD in human monocytic THP-1 cells: involvement of PKC, MEK/ERK and NOX-derived ROS. | 2012 May |
1 |
| 15 |
21077177 | Extracellular-superoxide dismutase expression during monocytic differentiation of U937 cells. | 2011 Jan |
1 |
| 16 |
21297032 | Molecular regulation of NADPH oxidase 5 via the MAPK pathway. | 2011 Apr |
1 |
| 17 |
21659537 | Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90(RSK) in the control of mTORC1 protein signaling by phorbol esters. | 2011 Aug 5 |
1 |
| 18 |
21730054 | Involvement of protein kinase Cdelta/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 (PARP-1) signaling pathway in histamine-induced up-regulation of histamine H1 receptor gene expression in HeLa cells. | 2011 Sep 2 |
1 |
| 19 |
20299489 | MicroRNA-34a inhibits cell proliferation by repressing mitogen-activated protein kinase kinase 1 during megakaryocytic differentiation of K562 cells. | 2010 Jun |
1 |
| 20 |
20592496 | Arsenic trioxide inhibits osteosarcoma cell invasiveness via MAPK signaling pathway. | 2010 Aug 1 |
1 |
| 21 |
19181503 | Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells. | 2009 Jun |
3 |
| 22 |
19715751 | Silibinin prevents TPA-induced MMP-9 expression by down-regulation of COX-2 in human breast cancer cells. | 2009 Nov 12 |
1 |
| 23 |
18053806 | A citrus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitor that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells. | 2008 Feb 1 |
3 |
| 24 |
18282472 | PKC and MEK pathways inhibit caspase-9/-3-mediated cytotoxicity in differentiated cells. | 2008 Mar 19 |
3 |
| 25 |
18519570 | Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase. | 2008 Jul 25 |
1 |
| 26 |
17101779 | Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma. | 2007 Feb |
2 |
| 27 |
17114644 | Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms. | 2007 May |
2 |
| 28 |
17131377 | Role of ROS and MAPK in TPA-induced ICAM-1 expression in the myeloid ML-1 cell line. | 2007 Mar 1 |
1 |
| 29 |
17394769 | Requirement for ERK activity in sodium selenite-induced apoptosis of acute promyelocytic leukemia-derived NB4 cells. | 2007 Mar 31 |
1 |
| 30 |
16169661 | Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2. | 2006 Jul 28 |
3 |
| 31 |
16267831 | Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1. | 2006 Jan |
1 |
| 32 |
16571380 | Histamine increases sphingosine kinase-1 expression and activity in the human arterial endothelial cell line EA.hy 926 by a PKC-alpha-dependent mechanism. | 2006 Mar |
1 |
| 33 |
16773182 | MUC5AC mucin gene regulation in pancreatic cancer cells. | 2006 Jul |
1 |
| 34 |
16868480 | On the mechanisms of 12-O-tetradecanoylphorbol-13-acetate-induced growth arrest in pancreatic cancer cells. | 2006 Aug |
2 |
| 35 |
17329956 | PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells. | 2006 |
3 |
| 36 |
15567061 | Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways. | 2005 Mar |
1 |
| 37 |
15721302 | Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2. | 2005 Apr 1 |
1 |
| 38 |
15757899 | Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells. | 2005 May 13 |
1 |
| 39 |
16351709 | p21WAF1 expression induced by MEK/ERK pathway activation or inhibition correlates with growth arrest, myogenic differentiation and onco-phenotype reversal in rhabdomyosarcoma cells. | 2005 Dec 13 |
1 |
| 40 |
14981539 | Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway. | 2004 Mar 11 |
1 |
| 41 |
15147830 | Negative regulation of the protein kinase C activator-induced ICAM-1 expression in the human bronchial epithelial cell line NCI-H292 by p44/42 mitogen-activated protein kinase. | 2004 Jun 11 |
2 |
| 42 |
12446683 | The ERK/MAPK pathway regulates the activity of the human tissue factor pathway inhibitor-2 promoter. | 2003 Feb 28 |
2 |
| 43 |
12592382 | ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. | 2003 Feb 20 |
1 |
| 44 |
12851698 | NAMI-A inhibits the PMA-induced ODC gene expression in ECV304 cells: involvement of PKC/Raf/Mek/ERK signalling pathway. | 2003 Aug |
1 |
| 45 |
12867426 | Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. | 2003 Sep 26 |
1 |
| 46 |
11799119 | The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites. | 2002 Mar 29 |
2 |
| 47 |
11914583 | Functional role of extracellular signal-regulated kinase activation and c-Jun induction in phorbol ester-induced promoter activation of human 12(S)-lipoxygenase gene. | 2002 Mar-Apr |
2 |
| 48 |
11940578 | c-Raf/MEK/ERK pathway controls protein kinase C-mediated p70S6K activation in adult cardiac muscle cells. | 2002 Jun 21 |
1 |
| 49 |
11959794 | Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy. | 2002 Apr |
1 |
| 50 |
12009309 | Novel protein kinase C isoforms and mitogen-activated kinase kinase mediate phorbol ester-induced osteopontin expression. | 2002 Sep |
3 |