| 1 |
35087712 | Antiviral and anti-inflammatory drugs to combat COVID-19: Effects on cardiac ion channels and risk of ventricular arrhythmias. | 2022 |
1 |
| 2 |
32888379 | Risk Assessment of Drug-Induced Long QT Syndrome for Some COVID-19 Repurposed Drugs. | 2021 Jan |
1 |
| 3 |
33450182 | Cryo-EM Structure of K+-Bound hERG Channel Complexed with the Blocker Astemizole. | 2021 Mar 4 |
3 |
| 4 |
33829343 | Cardiac hERG K+ Channel as Safety and Pharmacological Target. | 2021 |
1 |
| 5 |
34736759 | Electrocardiogram-based index for the assessment of drug-induced hERG potassium channel block. | 2021 Nov-Dec |
1 |
| 6 |
34757159 | TSSF-hERG: A machine-learning-based hERG potassium channel-specific scoring function for chemical cardiotoxicity prediction. | 2021 Dec |
1 |
| 7 |
31557540 | High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants. | 2020 Mar |
2 |
| 8 |
31598634 | Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue. | 2020 Jul 1 |
1 |
| 9 |
31657676 | Probucol-induced hERG Channel Reduction can be Rescued by Matrine and Oxymatrine in vitro. | 2020 |
2 |
| 10 |
31730936 | Improving prediction of torsadogenic risk in the CiPA in silico model by appropriately accounting for clinical exposure. | 2020 Jan - Feb |
1 |
| 11 |
31810890 | Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology. | 2020 Jan 1 |
1 |
| 12 |
31919307 | Synthesis, crystal structures, antiproliferative activities and reverse docking studies of eight novel Schiff bases derived from benzil. | 2020 Jan 1 |
1 |
| 13 |
31935579 | Assessment of spatial heterogeneity of ventricular repolarization after multi-channel blocker drugs in healthy subjects. | 2020 Jun |
1 |
| 14 |
32253972 | The mutation L69P in the PAS domain of the hERG potassium channel results in LQTS by trafficking deficiency. | 2020 Dec |
1 |
| 15 |
32703555 | Inhibition of Human Ether-A-Go-Go-Related Gene (hERG) Potassium Current by the Novel Sotalol Analogue, Soestalol. | 2020 Jul |
2 |
| 16 |
32882214 | Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. | 2020 Oct 15 |
1 |
| 17 |
32999428 | The electrophysiological effect of cannabidiol on hERG current and in guinea-pig and rabbit cardiac preparations. | 2020 Sep 30 |
1 |
| 18 |
33147278 | Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia. | 2020 |
1 |
| 19 |
33437379 | L51P, a novel mutation in the PAS domain of hERG channel, confers long QT syndrome by impairing channel activation. | 2020 |
1 |
| 20 |
30792104 | Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline. | 2019 Apr 1 |
1 |
| 21 |
31017964 | Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. | 2019 |
1 |
| 22 |
31347753 | Classification of drug-induced hERG potassium-channel block from electrocardiographic T-wave features using artificial neural networks. | 2019 Nov |
1 |
| 23 |
31526813 | Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings. | 2019 Nov |
1 |
| 24 |
31621014 | Open-Access Activity Prediction Tools for Natural Products. Case Study: hERG Blockers. | 2019 |
1 |
| 25 |
31659098 | MicroRNA 362-3p Reduces hERG-related Current and Inhibits Breast Cancer Cells Proliferation. | 2019 Nov-Dec |
1 |
| 26 |
31882846 | Identification of a proton sensor that regulates conductance and open time of single hERG channels. | 2019 Dec 27 |
1 |
| 27 |
29305421 | Fluid flow modulates electrical activity in cardiac hERG potassium channels. | 2018 Mar 23 |
1 |
| 28 |
29617054 | Activation of voltage-gated sodium current and inhibition of erg-mediated potassium current caused by telmisartan, an antagonist of angiotensin II type-1 receptor, in HL-1 atrial cardiomyocytes. | 2018 Aug |
1 |
| 29 |
29806042 | Performance of Machine Learning Algorithms for Qualitative and Quantitative Prediction Drug Blockade of hERG1 channel. | 2018 May |
1 |
| 30 |
28556923 | Antiarrhythmic properties of ivabradine in an experimental model of Short-QT- Syndrome. | 2017 Sep |
1 |
| 31 |
26689773 | SKF-96365 blocks human ether-à-go-go-related gene potassium channels stably expressed in HEK 293 cells. | 2016 Feb |
1 |
| 32 |
28097003 | Application of a systems pharmacology model for translational prediction of hERG-mediated QTc prolongation. | 2016 Dec |
1 |
| 33 |
25903789 | Cardiac safety of lacosamide: the non-clinical perspective. | 2015 Nov |
1 |
| 34 |
25318749 | Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration. | 2014 Oct 1 |
2 |
| 35 |
23241319 | Interactions between hERG and KCNQ1 α-subunits are mediated by their COOH termini and modulated by cAMP. | 2013 Feb 15 |
2 |
| 36 |
23792956 | Regulation of the human ether-a-go-go-related gene (hERG) channel by Rab4 protein through neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2). | 2013 Jul 26 |
1 |
| 37 |
22303293 | Toward a New Gold Standard for Early Safety: Automated Temperature-Controlled hERG Test on the PatchLiner. | 2012 |
1 |
| 38 |
23020479 | Chaotic dynamics in cardiac aggregates induced by potassium channel block. | 2012 Sep |
1 |
| 39 |
23133669 | Ion conduction through the hERG potassium channel. | 2012 |
1 |
| 40 |
21120454 | hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine. | 2011 Feb |
1 |
| 41 |
21484263 | Synergic effects of β-estradiol and erythromycin on hERG currents. | 2011 May |
1 |
| 42 |
21774764 | Enhanced repolarization capacity: new potential antiarrhythmic strategy based on HERG channel activation. | 2011 |
1 |
| 43 |
21888984 | hERG potency estimates based upon dose solution analysis: What have we learned? | 2011 Nov-Dec |
1 |
| 44 |
19903464 | Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652. | 2010 Mar 25 |
1 |
| 45 |
20229012 | Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. | 2010 May |
1 |
| 46 |
20607461 | 1H, 13C and 15N chemical shift assignments for the N-terminal domain of the voltage-gated potassium channel-hERG. | 2010 Oct |
3 |
| 47 |
20738248 | Insights into the molecular mechanism of hERG1 channel activation and blockade by drugs. | 2010 |
1 |
| 48 |
21158686 | A pharmacologically validated, high-capacity, functional thallium flux assay for the human Ether-à-go-go related gene potassium channel. | 2010 Dec |
1 |
| 49 |
19159406 | Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro. | 2009 Feb |
1 |
| 50 |
18042732 | 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels. | 2008 Mar |
1 |