Sirolimus

mechanistic target of rapamycin kinase ; Mus musculus







573 Article(s)
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Pub. Year
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1 34264340 The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease. 2022 Mar 29 1
2 34370147 Synergistic effects of Rapamycin and Fluorouracil to treat a gastric tumor in a PTEN conditional deletion mouse model. 2022 Jan 3
3 34522005 mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1-GluA2 interaction in the nucleus accumbens. 2022 Feb 2
4 34642952 Regulation of electrogenic Na+ /HCO3 - cotransporter 1 (NBCe1) function and its dependence on m-TOR mediated phosphorylation of Ser245. 2022 Feb 2
5 34706270 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. 2022 Mar 17 1
6 34723336 Role of mTOR in the Development of Asthma in Mice With Cigarette Smoke-Induced Cellular Senescence. 2022 Mar 3 1
7 34902357 High fat diet-induced obesity leads to depressive and anxiety-like behaviors in mice via AMPK/mTOR-mediated autophagy. 2022 Feb 1
8 34902496 Autophagy of Spinal Microglia Affects the Activation of Microglia through the PI3K/AKT/mTOR Signaling Pathway. 2022 Feb 1 1
9 34922249 Dihydroartemisinin inhibits Lewis Lung carcinoma progression by inducing macrophages M1 polarization via AKT/mTOR pathway. 2022 Feb 2
10 35040438 Sensing of RNA stress by mTORC1 drives autoinflammation. 2022 Jan 18 1
11 35078569 [Ox-LDL/β2GPI/anti-β2GPI antibody complex promotes apoptosis and inflammatory factors expression in RAW264.7 cells]. 2022 Jan 1
12 35114332 Rapamycin ameliorates age-related hearing loss in C57BL/6J mice by enhancing autophagy in the SGNs. 2022 Feb 16 1
13 35128864 [Effect of electroacupuncture on hepatocyte autophagy and oxidative stress in SAMP8 mice by regulating AMPK/mTOR/ULK1 signaling pathway]. 2022 Jan 25 1
14 35132962 mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice. 2022 Feb 8 2
15 35135573 Prenatal inflammation causes obesity and abnormal lipid metabolism via impaired energy expenditure in male offspring. 2022 Feb 8 1
16 35136953 NPRL3 loss alters neuronal morphology, mTOR localization, cortical lamination, and seizure threshold. 2022 Feb 8 1
17 35159256 PROX1, a Key Mediator of the Anti-Proliferative Effect of Rapamycin on Hepatocellular Carcinoma Cells. 2022 Jan 27 1
18 35184679 Rapamycin ameliorates chronic intermittent hypoxia and sleep deprivation-induced renal damage via the mammalian target of rapamycin (mTOR)/NOD-like receptor protein 3 (NLRP3) signaling pathway. 2022 Mar 1
19 35190469 A Critical Period for Development of Cerebellar-Mediated Autism-Relevant Social Behavior. 2022 Mar 30 2
20 35208186 Molecular Mechanisms of Parathyroid Disorders in Chronic Kidney Disease. 2022 Jan 25 1
21 35276460 Activation of TLR4 induces inflammatory muscle injury via mTOR and NF-κB pathways in experimental autoimmune myositis mice. 2022 May 7 1
22 35295093 Rapamycin Improved Retinal Function and Morphology in a Mouse Model of Retinal Degeneration. 2022 4
23 35449295 Cylindromatosis drives synapse pruning and weakening by promoting macroautophagy through Akt-mTOR signaling. 2022 May 2
24 35550871 Adipose Rheb deficiency promotes miR-182-5p expression via the cAMP/PPARγ signaling pathway. 2022 May 10 1
25 35571122 Effect of Combined Mycophenolate and Rapamycin Treatment on Kidney Fibrosis in Murine Lupus Nephritis. 2022 1
26 35585885 Orcinol Glucoside Improves Senile Osteoporosis through Attenuating Oxidative Stress and Autophagy of Osteoclast via Activating Nrf2/Keap1 and mTOR Signaling Pathway. 2022 1
27 35609863 Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model. 2022 Jun 2
28 35624154 TGF-β promotes pericyte-myofibroblast transition in subretinal fibrosis through the Smad2/3 and Akt/mTOR pathways. 2022 May 1
29 32207633 Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma. 2021 Apr 1
30 32738450 p53 haploinsufficiency and increased mTOR signalling define a subset of aggressive hepatocellular carcinoma. 2021 Jan 1
31 32944864 Astaxanthin Improved the Cognitive Deficits in APP/PS1 Transgenic Mice Via Selective Activation of mTOR. 2021 Sep 1
32 33140268 Rapamycin Ameliorates Cognitive Impairments and Alzheimer's Disease-Like Pathology with Restoring Mitochondrial Abnormality in the Hippocampus of Streptozotocin-Induced Diabetic Mice. 2021 Feb 3
33 33162031 The protective effects of rapamycin pretreatment on ovarian damage during ovarian tissue cryopreservation and transplantation. 2021 Jan 1 1
34 33259779 Stomach-specific c-Myc overexpression drives gastric adenoma in mice through AKT/mammalian target of rapamycin signaling. 2021 Aug 1 1
35 33352197 Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes. 2021 Feb 3
36 33352257 Arsenic-induced autophagy regulates apoptosis in AML-12 cells. 2021 Apr 1
37 33383488 Rapamycin alleviates cognitive impairment in murine vascular dementia: The enhancement of mitophagy by PI3K/AKT/mTOR axis. 2021 Apr 1
38 33462182 Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ROS-dependent TFEB nuclear translocation and AKT/mTOR pathway. 2021 Jan 18 1
39 33469286 Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer. 2021 1
40 33522374 Ligustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway. 2021 Dec 1
41 33632817 Liver homeostasis is maintained by midlobular zone 2 hepatocytes. 2021 Feb 26 1
42 33646885 Duloxetine suppresses BMP-4-induced release of osteoprotegerin via inhibition of the SMAD signaling pathway in osteoblasts. 2021 Oct 1
43 33708630 High-Fat Diet-Related Obesity Promotes Urethane-Induced Lung Tumorigenesis in C57BL/6J Mice. 2021 1
44 33758188 Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway. 2021 Mar 23 1
45 33769701 mTOR-mediated calcium transients affect cardiac function in ex vivo ischemia-reperfusion injury. 2021 Mar 1
46 33813773 L-leucine promotes axonal outgrowth and regeneration via mTOR activation. 2021 May 1
47 33860440 The mTOR/NF-κB Pathway Mediates Neuroinflammation and Synaptic Plasticity in Diabetic Encephalopathy. 2021 Aug 1
48 33888602 mTOR Attenuation with Rapamycin Reverses Neurovascular Uncoupling and Memory Deficits in Mice Modeling Alzheimer's Disease. 2021 May 12 1
49 33894212 Branched chain amino acids selectively promote cardiac growth at the end of the awake period. 2021 Aug 1
50 33910029 Rapamycin, but not minocycline, significantly alters ultrasonic vocalization behavior in C57BL/6J pups in a flurothyl seizure model. 2021 Jul 23 1