Leucine

mechanistic target of rapamycin kinase ; Mus musculus







32 Article(s)
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1 34843932 Methionine and leucine induce ARID1A degradation to promote mTOR expression and milk synthesis in mammary epithelial cells. 2022 Mar 2
2 33813773 L-leucine promotes axonal outgrowth and regeneration via mTOR activation. 2021 May 4
3 34126555 The involvement of Sestrin2 in the effect of IGF-I and leucine on mTROC1 activity in C2C12 and L6 myocytes. 2021 Aug 2
4 34801078 Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model. 2021 Nov 20 4
5 31475823 CRTC2 Is a Key Mediator of Amino Acid-Induced Milk Fat Synthesis in Mammary Epithelial Cells. 2019 Sep 18 1
6 31668641 Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. 2019 Dec 17 1
7 29802157 Defect of branched-chain amino acid metabolism promotes the development of Alzheimer's disease by targeting the mTOR signaling. 2018 Aug 31 2
8 30014636 [Effects of Phenylalanine on Glucose Uptake in Mouse Myoblast Cell Line C2C12 and Its Relationship with mTOR-p70S6K Pathway]. 2018 May 1
9 30084798 Leucine can modulate the expression of proteins related to protein degradation signalling under mTOR inhibition in C2C12 cells. 2018 Jul 30 2
10 28237591 Methionine, leucine, isoleucine, or threonine effects on mammary cell signaling and pup growth in lactating mice. 2017 May 1
11 28341273 Branched-chain amino acids enhance cyst development in autosomal dominant polycystic kidney disease. 2017 Aug 2
12 26745679 Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1α knockout mice. 2016 1
13 27327351 Differential effects of leucine supplementation in young and aged mice at the onset of skeletal muscle regeneration. 2016 Jul 1
14 27617277 The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation at the onset of skeletal muscle regeneration. 2016 Sep 2
15 25529824 The combination of ursolic acid and leucine potentiates the differentiation of C2C12 murine myoblasts through the mTOR signaling pathway. 2015 Mar 1
16 25575490 Leucine supplementation does not affect protein turnover and impairs the beneficial effects of endurance training on glucose homeostasis in healthy mice. 2015 Apr 1
17 25774780 High-fat feeding impairs nutrient sensing and gut brain integration in the caudomedial nucleus of the solitary tract in mice. 2015 1
18 26037201 Intestinal mTOR regulates GLP-1 production in mouse L cells. 2015 Aug 1
19 24586861 The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. 2014 1
20 24685128 Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice. 2014 Mar 31 3
21 25439029 Increasing leucine concentration stimulates mechanistic target of rapamycin signaling and cell growth in C2C12 skeletal muscle cells. 2014 Nov 4
22 22056783 Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo. 2012 Jan 15 1
23 22648621 Leucine induces myofibrillar protein accretion in cultured skeletal muscle through mTOR dependent and -independent control of myosin heavy chain mRNA levels. 2012 May 2
24 20151325 Leucine promotes leptin receptor expression in mouse C2C12 myotubes through the mTOR pathway. 2011 Jun 1
25 20851890 Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. 2010 Nov 19 3
26 17978888 Antagonistic effects of leucine and glutamine on the mTOR pathway in myogenic C2C12 cells. 2008 Jun 4
27 18616983 Branched-chain amino acids and arginine suppress MaFbx/atrogin-1 mRNA expression via mTOR pathway in C2C12 cell line. 2008 Oct 1
28 17178807 Leucine stimulates mammalian target of rapamycin signaling in C2C12 myoblasts in part through inhibition of adenosine monophosphate-activated protein kinase. 2007 Apr 1
29 17623010 Effect of branched-chain amino acids on muscle atrophy in cancer cachexia. 2007 Oct 1 1
30 16772439 Leucine activates pancreatic translational machinery in rats and mice through mTOR independently of CCK and insulin. 2006 Jul 1
31 15479767 Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. 2004 Dec 1
32 12801981 Amino acid transport regulates blastocyst implantation. 2003 Oct 1