| 1 |
32777735 | Isocitrate dehydrogenase variants in cancer - Cellular consequences and therapeutic opportunities. | 2020 Aug |
1 |
| 2 |
32900482 | SUMOylation enhances the activity of IDH2 under oxidative stress. | 2020 Nov 19 |
3 |
| 3 |
32955829 | Enasidenib and ivosidenib in AML. | 2020 Oct |
2 |
| 4 |
26865387 | Downregulation of IDH2 exacerbates H2O2-mediated cell death and hypertrophy. | 2017 Jan |
1 |
| 5 |
28267914 | Activity Based Protein Profiling Leads to Identification of Novel Protein Targets for Nerve Agent VX. | 2017 Apr 17 |
1 |
| 6 |
28375741 | Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development. | 2017 Jun 20 |
1 |
| 7 |
28653623 | Replication Study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. | 2017 Jun 27 |
1 |
| 8 |
29184081 | Allosteric inhibitor remotely modulates the conformation of the orthestric pockets in mutant IDH2/R140Q. | 2017 Nov 28 |
1 |
| 9 |
26774511 | 1,25-Dihydroxyvitamin D induces the glutamate transporter SLC1A1 and alters glutamate handling in non-transformed mammary cells. | 2016 Mar 15 |
1 |
| 10 |
26819452 | Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer. | 2016 Apr 15 |
4 |
| 11 |
27113762 | SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense. | 2016 Jun |
3 |
| 12 |
27355333 | Targeting isocitrate dehydrogenase (IDH) in cancer. | 2016 May |
1 |
| 13 |
28480226 | In vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation. | 2016 May |
2 |
| 14 |
24642088 | 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144. | 2014 Jun |
1 |
| 15 |
24747768 | Glutamate as chemotactic fuel for diffuse glioma cells: are they glutamate suckers? | 2014 Aug |
1 |
| 16 |
24880135 | The driver and passenger effects of isocitrate dehydrogenase 1 and 2 mutations in oncogenesis and survival prolongation. | 2014 Dec |
2 |
| 17 |
23500467 | Silencing of mitochondrial NADP(+)-dependent isocitrate dehydrogenase gene enhances glioma radiosensitivity. | 2013 Apr 5 |
2 |
| 18 |
23876293 | Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion. | 2013 Nov |
1 |
| 19 |
23949315 | Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia. | 2013 Oct |
1 |
| 20 |
22197820 | Regulation of brefeldin A-induced ER stress and apoptosis by mitochondrial NADP⁺-dependent isocitrate dehydrogenase. | 2012 Jan 13 |
2 |
| 21 |
22675360 | The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells. | 2012 |
4 |
| 22 |
22899282 | A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation. | 2012 Dec |
1 |
| 23 |
23226729 | Altered expression levels of IDH2 are involved in the development of colon cancer. | 2012 Nov |
3 |
| 24 |
21110780 | Suppression of mitochondrial NADP(+)-dependent isocitrate dehydrogenase activity enhances curcumin-induced apoptosis in HCT116 cells. | 2011 Apr |
2 |
| 25 |
21289278 | Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. | 2011 Feb 22 |
1 |
| 26 |
21326614 | 2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations. | 2011 Feb 4 |
1 |
| 27 |
21641335 | Glioma-derived mutations in isocitrate dehydrogenase 2 beneficial to traditional chemotherapy. | 2011 Jul 1 |
1 |
| 28 |
21647152 | Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML-BFM and DCOG study groups. | 2011 Nov |
1 |
| 29 |
21741430 | Attenuated mitochondrial NADP+-dependent isocitrate dehydrogenase activity enhances EGCG-induced apoptosis. | 2011 Oct |
2 |
| 30 |
22002076 | Isocitrate dehydrogenase mutations in gliomas: mechanisms, biomarkers and therapeutic target. | 2011 Dec |
2 |
| 31 |
22106302 | Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. | 2011 Dec 6 |
1 |
| 32 |
20088709 | Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase gene enhances selenite-induced apoptosis. | 2010 Mar |
2 |
| 33 |
20142433 | Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. | 2010 Feb 15 |
2 |
| 34 |
20421455 | Prognostic impact of IDH2 mutations in cytogenetically normal acute myeloid leukemia. | 2010 Jul 29 |
1 |
| 35 |
20603105 | IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain. | 2010 Jul 30 |
3 |
| 36 |
20713124 | Modulation of hypoxia-inducible factor-1α expression by mitochondrial NADP+-dependent isocitrate dehydrogenase. | 2010 Dec |
1 |
| 37 |
19228619 | IDH1 and IDH2 mutations in gliomas. | 2009 Feb 19 |
1 |
| 38 |
19500645 | Regulation of ethanol-induced toxicity by mitochondrial NADP(+)-dependent isocitrate dehydrogenase. | 2009 Aug |
2 |
| 39 |
18096511 | Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. | 2008 Feb 22 |
1 |
| 40 |
18484410 | Inactivation of mitochondrial NADP+-dependent isocitrate dehydrogenase by hypochlorous acid. | 2008 May |
2 |
| 41 |
17075901 | Mitochondrial isocitrate dehydrogenase protects human neuroblastoma SH-SY5Y cells against oxidative stress. | 2007 Jan |
3 |
| 42 |
17350954 | Regulation of ionizing radiation-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase. | 2007 May 4 |
1 |
| 43 |
17854715 | Small interfering RNA-mediated silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase enhances the sensitivity of HeLa cells toward tumor necrosis factor-alpha and anticancer drugs. | 2007 Oct 15 |
1 |
| 44 |
16337884 | Regulation of replicative senescence by NADP+ -dependent isocitrate dehydrogenase. | 2006 Jan 1 |
1 |
| 45 |
16028369 | Cellular defense against heat shock-induced oxidative damage by mitochondrial NADP+ -dependent isocitrate dehydrogenase. | 2005 Apr |
1 |
| 46 |
15522197 | Regulation of high glucose-induced apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase. | 2004 Dec 3 |
1 |
| 47 |
11278619 | Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase. | 2001 May 11 |
2 |
| 48 |
8954790 | Assignment of the human mitochondrial NADP(+)-specific isocitrate dehydrogenase (IDH2) gene to 15q26.1 by in situ hybridization. | 1996 Nov 15 |
1 |
| 49 |
564083 | Somatic cell genetic assignment of the human gene for mitochondrial NADP-linked isocitrate dehydrogenase to the long arm of chromosome 15. | 1977 Jan |
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