| 1 |
35048959 | Human lactate dehydrogenase A undergoes allosteric transitions under pH conditions inducing the dissociation of the tetrameric enzyme. | 2022 Jan 28 |
3 |
| 2 |
35124385 | Oxamate targeting aggressive cancers with special emphasis to brain tumors. | 2022 Mar |
2 |
| 3 |
33708985 | Aberrant lactate dehydrogenase A signaling contributes metabolic signatures in pancreatic cancer. | 2021 Feb |
1 |
| 4 |
33742144 | Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer. | 2021 May |
1 |
| 5 |
33953846 | Down regulation of lactate dehydrogenase initiates apoptosis in HeLa and MCF-7 cancer cells through increased voltage-dependent anion channel protein and inhibition of BCL2. | 2021 Apr 27 |
2 |
| 6 |
33966212 | An Observation on Enhanced Extracellular Acidification and Lactate Production Induced by Inhibition of Lactate Dehydrogenase A. | 2021 |
2 |
| 7 |
34020698 | Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs. | 2021 May 21 |
1 |
| 8 |
34086382 | Visualizing the effects of lactate dehydrogenase (LDH) inhibition and LDH-A genetic ablation in breast and lung cancer with hyperpolarized pyruvate NMR. | 2021 Aug |
2 |
| 9 |
34110068 | LDH-A negatively regulates dMMR in colorectal cancer. | 2021 Aug |
2 |
| 10 |
34181805 | The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets. | 2021 Sep |
2 |
| 11 |
34217973 | LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes. | 2021 Sep 3 |
2 |
| 12 |
34278456 | Hypoxia‑induced lactate dehydrogenase A protects cells from apoptosis in endometriosis. | 2021 Sep |
2 |
| 13 |
34625424 | Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients. | 2021 Dec 1 |
3 |
| 14 |
34725423 | Identification of the first highly selective inhibitor of human lactate dehydrogenase B. | 2021 Nov 1 |
1 |
| 15 |
32123312 | Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition. | 2020 Apr |
1 |
| 16 |
32523242 | Sirtuin 6 and metabolic genes interplay in Warburg effect in cancers. | 2020 May |
1 |
| 17 |
30866966 | Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis. | 2019 Mar 12 |
1 |
| 18 |
31035592 | Unappreciated Role of LDHA and LDHB to Control Apoptosis and Autophagy in Tumor Cells. | 2019 Apr 27 |
5 |
| 19 |
31100640 | Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis. | 2019 Jul |
2 |
| 20 |
31229799 | The NIR inspired nano-CuSMn(II) composites for lactate and glycolysis attenuation. | 2019 Sep 1 |
1 |
| 21 |
31717879 | Mineral-Enriched Deep-Sea Water Modulates Lactate Metabolism via PGC-1α-Mediated Metabolic Reprogramming. | 2019 Oct 27 |
1 |
| 22 |
29482580 | Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation. | 2018 Feb 26 |
1 |
| 23 |
29552147 | Silencing LDHA inhibits proliferation, induces apoptosis and increases chemosensitivity to temozolomide in glioma cells. | 2018 Apr |
2 |
| 24 |
29740212 | LDH-Apromotes epithelial-mesenchymal transition by upregulating ZEB2 in intestinal-type gastric cancer. | 2018 |
2 |
| 25 |
30158244 | Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. | 2018 Oct 12 |
2 |
| 26 |
30189677 | Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. | 2018 Sep 5 |
2 |
| 27 |
30403008 | Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy. | 2018 Dec |
2 |
| 28 |
27027898 | Inhibition of LDHA Deliver Potential Anticancer Performance in Renal Cell Carcinoma. | 2017 |
2 |
| 29 |
27622920 | Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells. | 2017 Jan 1 |
2 |
| 30 |
28193910 | HIF1/2α mediates hypoxia-induced LDHA expression in human pancreatic cancer cells. | 2017 Apr 11 |
2 |
| 31 |
28218905 | Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis. | 2017 Jul 6 |
2 |
| 32 |
28371597 | Role of Proton Pumps in Tumorigenesis. | 2017 Apr |
1 |
| 33 |
28404377 | H2S-induced S-sulfhydration of lactate dehydrogenase a (LDHA) stimulates cellular bioenergetics in HCT116 colon cancer cells. | 2017 Jul 15 |
2 |
| 34 |
28582845 | Elevated lactate dehydrogenase (LDH) can be a marker of immune suppression in cancer: Interplay between hematologic and solid neoplastic clones and their microenvironments. | 2017 Jul 4 |
3 |
| 35 |
28689265 | Aerobic Glycolysis Hypothesis Through WNT/Beta-Catenin Pathway in Exudative Age-Related Macular Degeneration. | 2017 Aug |
1 |
| 36 |
28950656 | Oxamate potentiates taxol chemotherapeutic efficacy in experimentally-induced solid ehrlich carcinoma (SEC) in mice. | 2017 Nov |
2 |
| 37 |
26694942 | Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma. | 2016 Jan 20 |
2 |
| 38 |
27822418 | Inhibition of mTORC1 signaling sensitizes hepatocellular carcinoma cells to glycolytic stress. | 2016 |
2 |
| 39 |
25394466 | Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells. | 2015 Jan |
2 |
| 40 |
25664730 | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. | 2015 Feb |
1 |
| 41 |
25789051 | Synergistic cytotoxicity of cisplatin and Taxol in overcoming Taxol resistance through the inhibition of LDHA in oral squamous cell carcinoma. | 2015 Apr |
3 |
| 42 |
25913622 | Expression of SIP1 is strongly correlated with LDHA and shows a significantly poor outcome in gastric cancer. | 2015 Sep |
2 |
| 43 |
25934158 | Screening of novel inhibitors targeting lactate dehydrogenase A via four molecular docking strategies and dynamics simulations. | 2015 May |
2 |
| 44 |
26021472 | The c-Myc-LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer. | 2015 Jul |
2 |
| 45 |
26085945 | Search for Human Lactate Dehydrogenase A Inhibitors Using Structure-Based Modeling. | 2015 Apr-Jun |
1 |
| 46 |
26113084 | Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function. | 2015 Aug 15 |
2 |
| 47 |
26246802 | Metabolic Consequences of LDHA inhibition by Epigallocatechin Gallate and Oxamate in MIA PaCa-2 Pancreatic Cancer Cells. | 2015 Feb |
2 |
| 48 |
26261559 | FOXM1-LDHA signaling promoted gastric cancer glycolytic phenotype and progression. | 2015 |
2 |
| 49 |
26494310 | Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death. | 2015 Oct 23 |
2 |
| 50 |
24608789 | Clinicopathological significance and prognostic value of lactate dehydrogenase A expression in gastric cancer patients. | 2014 |
1 |