Doxorubicin

ATP binding cassette subfamily C member 1 ; Homo sapiens







171 Article(s)
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51 25603048 ABCB1, ABCC1, and LRP gene expressions are altered by LDL, HDL, and serum deprivation in a human doxorubicin-resistant uterine sarcoma cell line. 2015 Feb 20 1
52 25934574 Chimeric MicroRNA-1291 Biosynthesized Efficiently in Escherichia coli Is Effective to Reduce Target Gene Expression in Human Carcinoma Cells and Improve Chemosensitivity. 2015 Jul 1
53 26063481 Lapatinib sensitizes quiescent MDA-MB-231 breast cancer cells to doxorubicin by inhibiting the expression of multidrug resistance-associated protein-1. 2015 Aug 6
54 26318721 MicroRNA-134 modulates resistance to doxorubicin in human breast cancer cells by downregulating ABCC1. 2015 Dec 4
55 26362310 Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy. 2015 Sep 11 5
56 26600514 Meloxicam increases intracellular accumulation of doxorubicin via downregulation of multidrug resistance-associated protein 1 (MRP1) in A549 cells. 2015 Nov 19 4
57 24161697 Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin. 2014 Jan 2
58 24491315 Oleanolic and maslinic acid sensitize soft tissue sarcoma cells to doxorubicin by inhibiting the multidrug resistance protein MRP-1, but not P-glycoprotein. 2014 Apr 1
59 24956120 Flavonostilbenes from Sophora alopecuroides L. as multidrug resistance associated protein 1 (MRP1) inhibitors. 2014 1
60 25057799 Liposomal nitrooxy-doxorubicin: one step over caelyx in drug-resistant human cancer cells. 2014 Sep 2 1
61 25105301 Lapatinib antagonizes multidrug resistance-associated protein 1-mediated multidrug resistance by inhibiting its transport function. 2014 Sep 8 2
62 25338578 [Reversal effect of cinobufacini on multidrug resistance of Raji/ADR cells and its mechanisms]. 2014 Oct 4
63 22882382 Increased glutathione and mitogen-activated protein kinase phosphorylation are involved in the induction of doxorubicin resistance in hepatocellular carcinoma cells. 2013 Mar 1
64 23320839 MEK inhibition induced downregulation of MRP1 and MRP3 expression in experimental hepatocellular carcinoma. 2013 Jan 15 2
65 23686318 Small nucleolar RNA-derived microRNA hsa-miR-1291 modulates cellular drug disposition through direct targeting of ABC transporter ABCC1. 2013 Oct 1
66 24040940 Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors. 2013 Sep 17 1
67 32481901 Enhanced intracellular drug delivery of pH-sensitive doxorubicin/poly(ethylene glycol)-block-poly(4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells. 2013 Apr 5 2
68 22293538 The G671V variant of MRP1/ABCC1 links doxorubicin-induced acute cardiac toxicity to disposition of the glutathione conjugate of 4-hydroxy-2-trans-nonenal. 2012 Apr 5
69 22510476 miR-126 enhances the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting vascular endothelial growth factor A. 2012 Jun 2
70 22571463 The transcription factor GCF2 is an upstream repressor of the small GTPAse RhoA, regulating membrane protein trafficking, sensitivity to doxorubicin, and resistance to cisplatin. 2012 Jun 4 2
71 22787275 Collagen/β1 integrin signaling up-regulates the ABCC1/MRP-1 transporter in an ERK/MAPK-dependent manner. 2012 Sep 5
72 20563580 Effect of MDR modulators verapamil and promethazine on gene expression levels of MDR1 and MRP1 in doxorubicin-resistant MCF-7 cells. 2011 Apr 1
73 21143116 Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1). 2011 2
74 21377266 Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein and MRP1 expression. 2011 May 28 3
75 21566063 Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. 2011 Jul 1
76 21571281 Rapid determination of multidrug resistance-associated protein in cancer cells by capillary electrophoresis immunoassay. 2011 Jun 24 3
77 21679161 Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity. 2011 Oct 1 1
78 21903448 Nuclear translocation of MRP1 contributes to multidrug resistance of mucoepidermoid carcinoma. 2011 Dec 1
79 21968975 Infection of H69AR cells with retroviral particles harboring interfering RNAi significantly reduced the multidrug resistance of these small cell lung cancer cells. 2011 1
80 22094098 [Effect of RAD001 or plus LBH589 on the proliferation, apoptosis and drug resistance in chemoresistant acute myeloid leukemic cells]. 2011 Aug 30 1
81 22101388 How circulating tumor cells escape from multidrug resistance: translating molecular mechanisms in metastatic breast cancer treatment. 2011 Dec 1
82 20037485 Synergistic action of doxorubicin and sulindac in human cervix carcinoma cells - studies on possible mechanisms. 2010 Jan 2
83 20137116 [Effects of compound Zhe-Bei granule (CZBG) combined with doxorubicin on expression of membrane transport proteins in K562/A02 cell xenografts]. 2010 Feb 1
84 20339089 Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome. 2010 Jul 22 3
85 20350534 Resveratrol-mediated reversal of doxorubicin resistance in acute myeloid leukemia cells via downregulation of MRP1 expression. 2010 Apr 23 4
86 20532504 Polymorphisms in the multiple drug resistance protein 1 and in P-glycoprotein 1 are associated with time to event outcomes in patients with advanced multiple myeloma treated with bortezomib and pegylated liposomal doxorubicin. 2010 Nov 1
87 18828019 Diverse cross-resistance phenotype to ET-743 and PM00104 in multi-drug resistant cell lines. 2009 May 1
88 18924151 The pH sensitive probe 5-(and-6)-carboxyl seminaphthorhodafluor is a substrate for the multidrug resistance-related protein MRP1. 2009 Jan 1 1
89 19120455 Competition between innate multidrug resistance and intracellular binding of rhodamine dyes. 2009 Feb 1
90 19214144 Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population. 2009 Mar 1
91 19390592 Vandetanib (Zactima, ZD6474) antagonizes ABCC1- and ABCG2-mediated multidrug resistance by inhibition of their transport function. 2009 1
92 19725578 Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives. 2009 Sep 10 9
93 18560228 Effect of doxorubicin on telomerase activity and apoptotic gene expression in doxorubicin-resistant and -sensitive MCF-7 cells: an experimental study. 2008 2
94 19175986 [Mechanism of synergistic anti-tumor effect of PH II -7 with doxorubicin on multi-drug resistant HL-60/ADR cells]. 2008 Sep 2
95 20020937 Role of ABC Transporters in the BeWo Trophoblast Cell Line. 2008 Jan 1
96 17072745 The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells. 2007 Apr 1
97 17129588 Dibenzocyclooctadiene lignans: a class of novel inhibitors of multidrug resistance-associated protein 1. 2007 Jan 30 2
98 17352253 Modulatory effects of heparin on cellular accumulation and cytotoxicity of doxorubicin in MRP1-overexpressing HL60/doxo cells. 2007 Jan-Feb 2
99 17520676 Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells. 2007 Sep 15 2
100 16049968 Involvement of P-glycoprotein and MRP1 in resistance to cyclic tetrapeptide subfamily of histone deacetylase inhibitors in the drug-resistant osteosarcoma and Ewing's sarcoma cells. 2006 Jan 1 3