Glutathione

glutamate-cysteine ligase, catalytic subunit ; Rattus norvegicus







149 Article(s)
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1 33431776 Protective Effect of Nervonic Acid Against 6-Hydroxydopamine-Induced Oxidative Stress in PC-12 Cells. 2021 2
2 33508284 Oxindole-curcumin hybrid compound enhances the transcription of γ-glutamylcysteine ligase. 2021 Apr 5 1
3 34064070 C60 Fullerene Reduces 3-Nitropropionic Acid-Induced Oxidative Stress Disorders and Mitochondrial Dysfunction in Rats by Modulation of p53, Bcl-2 and Nrf2 Targeted Proteins. 2021 May 21 2
4 34950419 Response of Cytoprotective and Detoxifying Proteins to Vanadate and/or Magnesium in the Rat Liver: The Nrf2-Keap1 System. 2021 2
5 32932938 Restraint Stress Alters Expression of Glucocorticoid Bioavailability Mediators, Suppresses Nrf2, and Promotes Oxidative Stress in Liver Tissue. 2020 Sep 11 2
6 31210340 Ambroxol alleviates ventilator-induced lung injury by inhibiting c-Jun expression. 2019 Jun 4
7 27318675 Mangiferin Upregulates Glyoxalase 1 Through Activation of Nrf2/ARE Signaling in Central Neurons Cultured with High Glucose. 2017 Aug 1
8 27718499 Amentoflavone prevents sepsis-associated acute lung injury through Nrf2-GCLc-mediated upregulation of glutathione. 2017 1
9 28390315 Glutathione inhibits antibody and complement-mediated immunologic cell injury via multiple mechanisms. 2017 Aug 1
10 27082705 Attenuation of renal ischemia/reperfusion injury by oleanolic acid preconditioning via its antioxidant, anti‑inflammatory, and anti‑apoptotic activities. 2016 Jun 1
11 24849033 Involvement of Nrf2-GSH signaling in TGFβ1-stimulated epithelial-to-mesenchymal transition changes in rat renal tubular cells. 2015 Feb 3
12 25549939 Cystamine induces AIF-mediated apoptosis through glutathione depletion. 2015 Mar 1
13 26269092 Paeoniflorin ameliorates ANIT-induced cholestasis by activating Nrf2 through an PI3K/Akt-dependent pathway in rats. 2015 Nov 3
14 24609977 Roles of glutathione in antioxidant defense, inflammation, and neuron differentiation in the thalamus of HIV-1 transgenic rats. 2014 Jun 1
15 25016074 Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression. 2014 Oct 3
16 22212472 Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver? 2012 Apr 1
17 22486866 Attenuation of cysteamine-induced duodenal ulcer with Cochinchina momordica seed extract through inhibiting cytoplasmic phospholipase A2/5-lipoxygenase and activating γ-glutamylcysteine synthetase. 2012 Apr 3
18 22542796 Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: role of nuclear factor-erythroid 2-related factor 2. 2012 May 15 3
19 21036165 Proteasome inhibitor up regulates liver antioxidative enzymes in rat model of alcoholic liver disease. 2011 Feb 2
20 21358121 Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate. 2011 5
21 20420805 DHEA attenuates PDGF-induced phenotypic proliferation of vascular smooth muscle A7r5 cells through redox regulation. 2010 May 28 2
22 20535554 Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells. 2010 Oct 1
23 18042181 FSH and bFGF stimulate the production of glutathione in cultured rat Sertoli cells. 2009 Jun 1
24 19104759 Dietary selenium (Se) and copper (Cu) interact to affect homocysteine metabolism in rats. 2009 Summer 1
25 19144757 Differences in lung glutathione metabolism may account for rodent susceptibility in elastase-induced emphysema development. 2009 Apr 1
26 19193864 Nitric oxide-mediated protection of endothelial cells from hydrogen peroxide is mediated by intracellular zinc and glutathione. 2009 Apr 4
27 19516019 Follicle-stimulating hormone and estradiol interact to stimulate glutathione synthesis in rat ovarian follicles and granulosa cells. 2009 Oct 1
28 19798679 Quercetin-induced upregulation of human GCLC gene is mediated by cis-regulatory element for early growth response protein-1 (EGR1) in INS-1 beta-cells. 2009 Dec 15 2
29 18379079 Pectolinarin and Pectolinarigenin of Cirsium setidens Prevent the Hepatic Injury in Rats Caused by D-Galactosamine via an Antioxidant Mechanism. 2008 Apr 1
30 18690414 Renal antioxidant enzymes and glutathione redox status in leptin-induced hypertension. 2008 Dec 2
31 17681938 Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling. 2007 Sep 28 1
32 16137247 Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation. 2006 Jan 1 2
33 16183247 Minimal ovarian upregulation of glutamate cysteine ligase expression in response to suppression of glutathione by buthionine sulfoximine. 2006 Feb 1
34 16549430 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells. 2006 May 12 1
35 16647047 Age-related changes in glutathione and glutathione-related enzymes in rat brain. 2006 May 23 1
36 15811874 Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific. 2005 Sep 3
37 16011481 Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1. 2005 Oct 15 2
38 16409822 [Cigarette smoking coacervate up-regulates the expression of gamma-glutamylcysteine synthetase in alveolar epithelial cells mediated by activator protein-1]. 2005 Dec 7 2
39 15169830 Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes. 2004 Oct 1
40 15451066 Role of glutathione in the adaptive tolerance to H2O2. 2004 Oct 15 2
41 12535742 Induction of cellular glutathione and glutathione S-transferase by 3H-1,2-dithiole-3-thione in rat aortic smooth muscle A10 cells: protection against acrolein-induced toxicity. 2003 Feb 1
42 12628495 Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach. 2003 Mar 1 2
43 12723969 Inhibition of liver trans-sulphuration pathway by propargylglycine mimics gene expression changes found in the mammary gland of weaned lactating rats: role of glutathione. 2003 Aug 1 1
44 12967637 Regulation of glutathione in cardiac myocytes. 2003 Sep 1
45 11744015 Up-regulation of K(+) channels in diabetic rat ventricular myocytes by insulin and glutathione. 2002 Jan 2
46 11876501 The coffee components kahweol and cafestol induce gamma-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat. 2002 Jan 3
47 11950820 Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats. 2002 May 1
48 12003845 Glutathione and K(+) channel remodeling in postinfarction rat heart. 2002 Jun 1
49 12111865 Down-regulation of gamma-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging. 2002 May 1 4
50 12388394 Increase in renal glutathione in cholestatic liver disease is due to a direct effect of bile acids. 2002 Dec 2