| 1 |
34982346 | Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor. | 2022 Apr |
1 |
| 2 |
35373585 | Dual endothelin receptor antagonism increases resting energy expenditure in people with increased adiposity. | 2022 Jun 1 |
2 |
| 3 |
35527471 | Endothelin-1 dependent expression of GAG genes involves NOX and p38 mediated Smad linker region phosphorylation. | 2022 Jul |
1 |
| 4 |
33359621 | Evaluation of the combination of endothelin receptor antagonists (ERA) and phosphodiesterase-5 inhibitors for the treatment of pulmonary arterial hypertension (PAH) in pathologic human pulmonary arteries in an ex-vivo organ bath model. | 2021 Feb |
1 |
| 5 |
33856498 | The Influence of Bosentan on MicroRNA-27a/PPARγ/ET-1 Signaling Pathway in Pulmonary Artery Hypertension. | 2021 Jun |
5 |
| 6 |
34199777 | Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53. | 2021 Jun 4 |
4 |
| 7 |
34837677 | EGF Receptor Transactivation by Endothelin-1 Increased CHSY-1 Mediated by NADPH Oxidase and Phosphorylation of ERK1/2. | 2021 Oct |
2 |
| 8 |
32765401 | The Role of Cerebral Hypoperfusion in Multiple Sclerosis (ROCHIMS) Trial in Multiple Sclerosis: Insights From Negative Results. | 2020 |
2 |
| 9 |
33209081 | Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells. | 2020 Oct |
7 |
| 10 |
30563869 | REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human systemic lupus erythematosus (SLE) through NETs decorated with tissue factor (TF) and interleukin-17A (IL-17A). | 2019 Feb |
1 |
| 11 |
29947542 | Lipopolysaccharide-induced necroptosis of brain microvascular endothelial cells can be prevented by inhibition of endothelin receptors. | 2018 Jun 27 |
1 |
| 12 |
30261985 | Titration of pulmonary arterial hypertension therapeutics: Experience-based recommendations. | 2018 Oct |
1 |
| 13 |
28401480 | Target-Mediated Drug Disposition Pharmacokinetic-Pharmacodynamic Model of Bosentan and Endothelin-1. | 2017 Dec |
3 |
| 14 |
28500979 | Ultra-sensitive and selective quantification of endothelin-1 in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry. | 2017 Aug 5 |
1 |
| 15 |
28597546 | Endothelin-1 receptor blockade as new possible therapeutic approach in multiple myeloma. | 2017 Sep |
1 |
| 16 |
27189349 | Antagonism of Endothelin (ETA and ETB) Receptors During Renovascular Hypertension-Induced Vascular Dementia Improves Cognition. | 2016 |
1 |
| 17 |
27716320 | Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study. | 2016 Oct 6 |
1 |
| 18 |
25593238 | Effects of macitentan and its active metabolite on cultured human systemic sclerosis and control skin fibroblasts. | 2015 Mar |
1 |
| 19 |
25707716 | Endothelin receptor blockade ameliorates vascular fragility in endothelial cell-specific Fli-1-knockout mice by increasing Fli-1 DNA binding ability. | 2015 May |
1 |
| 20 |
26090478 | Endothelin Receptors Expressed by Immune Cells Are Involved in Modulation of Inflammation and in Fibrosis: Relevance to the Pathogenesis of Systemic Sclerosis. | 2015 |
1 |
| 21 |
26111581 | Endothelin-1 receptor antagonists in fetal development and pulmonary arterial hypertension. | 2015 Aug 15 |
1 |
| 22 |
24071933 | Improvement of plasma endothelin-1 and nitric oxide in patients with systemic sclerosis by bosentan therapy. | 2014 Feb |
5 |
| 23 |
24193244 | Combination of sildenafil and bosentan for pulmonary hypertension in a human ex vivo model. | 2014 Feb |
1 |
| 24 |
24632478 | Unexpected pulmonary hypertensive crisis after surgery for ocular malignant melanoma. | 2014 Nov 24 |
1 |
| 25 |
25048859 | Role of endothelin-1/endothelin receptor signaling in fibrosis and calcification in nephrogenic systemic fibrosis. | 2014 Sep |
1 |
| 26 |
22265324 | Relationship between baseline ET-1 plasma levels and outcome in patients with idiopathic pulmonary hypertension treated with bosentan. | 2013 Jul 15 |
2 |
| 27 |
23359533 | Interferon-γ promotes vascular remodeling in human microvascular endothelial cells by upregulating endothelin (ET)-1 and transforming growth factor (TGF) β2. | 2013 Aug |
1 |
| 28 |
23509249 | Cerebral hypoperfusion in multiple sclerosis is reversible and mediated by endothelin-1. | 2013 Apr 2 |
1 |
| 29 |
23696678 | Targeting the endothelin axis in scleroderma renal crisis: rationale and feasibility. | 2013 Sep |
1 |
| 30 |
23984086 | Endothelin-1 levels in scleroderma patients: a pilot study. | 2013 |
1 |
| 31 |
24015303 | The interaction of endothelin-1 and TGF-β1 mediates vascular cell remodeling. | 2013 |
1 |
| 32 |
21432755 | Bosentan effects on hemodynamics and clinical outcome in heart failure patients with pulmonary hypertension awaiting cardiac transplantation. | 2012 Feb |
1 |
| 33 |
21828025 | Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries. | 2012 Apr |
4 |
| 34 |
22483689 | Endothelin-1 enhances β₂-adrenoceptor gene transcription in human lung fibroblasts. | 2012 Oct 15 |
1 |
| 35 |
22558517 | Bosentan effects in hypoxic pulmonary vasoconstriction: Preliminary study in subjects with or without high altitude pulmonary edema-history. | 2012 Jan-Mar |
1 |
| 36 |
22561246 | Purification and characterization of recombinant human endothelin receptor type A. | 2012 Jul |
1 |
| 37 |
23053682 | Bosentan fosters microvascular de-remodelling in systemic sclerosis. | 2012 Dec |
1 |
| 38 |
21777087 | Human recombinant erythropoietin alters the flow-dependent vasodilatation of in vitro perfused rat mesenteric arteries with unbalanced endothelial endothelin-1 / nitric oxide ratio. | 2011 Jun |
2 |
| 39 |
21834070 | Tissue factor-thrombin signaling enhances the fibrotic activity of myofibroblasts in systemic sclerosis through up-regulation of endothelin receptor A. | 2011 Nov |
1 |
| 40 |
19660388 | Bosentan as a bridge to pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension. | 2010 Jan |
1 |
| 41 |
19967386 | Endothelium-derived endothelin-1. | 2010 May |
1 |
| 42 |
20034342 | Bosentan: in pediatric patients with pulmonary arterial hypertension. | 2010 |
1 |
| 43 |
20131241 | Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis. | 2010 Mar |
1 |
| 44 |
20186146 | Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension. | 2010 May |
1 |
| 45 |
20625315 | Endothelin-1 stimulation of proteoglycan synthesis in vascular smooth muscle is mediated by endothelin receptor transactivation of the transforming growth factor-[beta] type I receptor. | 2010 Oct |
2 |
| 46 |
19217622 | Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL. | 2009 Aug |
1 |
| 47 |
19417139 | Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. | 2009 May 15 |
1 |
| 48 |
19747014 | Bosentan: a review of its use in the management of digital ulcers associated with systemic sclerosis. | 2009 Oct 1 |
1 |
| 49 |
19791841 | Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. | 2009 |
1 |
| 50 |
19850966 | TNFalpha-induced GM-CSF release from human airway smooth muscle cells depends on activation of an ET-1 autoregulatory positive feedback mechanism. | 2009 Dec |
5 |