| 1 |
30655952 | Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI). | 2019 Jan 10 |
2 |
| 2 |
25953200 | Omapatrilat: penetration across the blood-brain barrier and effects on ischaemic stroke in rats. | 2015 Sep |
4 |
| 3 |
21297495 | Concomitant angiotensin AT1 receptor antagonism and neprilysin inhibition produces omapatrilat-like antihypertensive effects without promoting tracheal plasma extravasation in the rat. | 2011 Apr |
2 |
| 4 |
18084312 | Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema. | 2008 Mar |
2 |
| 5 |
15498826 | Cardiac and renal effects of omapatrilat, a vasopeptidase inhibitor, in rats with experimental congestive heart failure. | 2005 Feb |
4 |
| 6 |
15659305 | Changes in production and metabolism of brain natriuretic peptide in rats with myocardial necrosis. | 2005 Jan 10 |
2 |
| 7 |
15662229 | Dual angiotensin-converting enzyme/neutral endopeptidase inhibition on cardiac and renal fibrosis and inflammation in DOCA-salt hypertensive rats. | 2005 Feb |
1 |
| 8 |
16003188 | Angiotensin I-converting enzyme-dependent and neutral endopeptidase-dependent generation and degradation of angiotensin II contrarily modulate noradrenaline release: implications for vasopeptidase-inhibitor therapy? | 2005 Aug |
3 |
| 9 |
16144980 | Mechanism of vasopeptidase inhibitor-induced plasma extravasation: comparison of omapatrilat and the novel neutral endopeptidase 24.11/angiotensin-converting enzyme inhibitor GW796406. | 2005 Dec |
1 |
| 10 |
16642666 | Dual inhibition of angiotensin converting enzyme and neutral endopeptidase produces effective blood pressure control in spontaneously hypertensive rats. | 2005 |
2 |
| 11 |
14769834 | The effect of acute angiotensin-converting enzyme and neutral endopeptidase 24.11 inhibition on plasma extravasation in the rat. | 2004 Jun |
2 |
| 12 |
15000298 | Cardiorenal protective effects of vasopeptidase inhibition with omapatrilat in hypertensive transgenic (mREN-2)27 rats. | 2004 Jan |
2 |
| 13 |
15004434 | Role of Angiotensin-converting enzyme and neutral endopeptidase in flow-dependent remodeling. | 2004 Mar-Apr |
2 |
| 14 |
12517680 | Effects of omapatrilat on blood pressure and renal injury in L-NAME and L-NAME plus DOCA-treated rats. | 2003 Jan |
1 |
| 15 |
12741953 | Differential tissue and enzyme inhibitory effects of the vasopeptidase inhibitor omapatrilat in the rat. | 2003 Sep |
2 |
| 16 |
12897822 | Bradykinin metabolism in rat hearts with left-ventricular hypertrophy following myocardial infarction. | 2003 Jul |
1 |
| 17 |
14573331 | Effect of dual angiotensin converting enzyme/neutral endopeptidase inhibition, angiotensin converting enzyme inhibition, or AT1 antagonism on coronary microvasculature in spontaneously hypertensive rats. | 2003 Nov |
3 |
| 18 |
14674703 | Comparative effects of a vasopeptidase inhibitor vs. an angiotensin converting enzyme inhibitor on cardiomyocyte apoptosis in rats with heart failure. | 2003 Dec |
1 |
| 19 |
14674706 | Direct inhibition of neutral endopeptidase in vasopeptidase inhibitor-mediated amelioration of cardiac remodeling in rats with chronic heart failure. | 2003 Dec |
2 |
| 20 |
15259792 | Omapatrilat increases renal endothelin in deoxycorticosterone acetate-salt hypertensive rats. | 2003 Dec |
1 |
| 21 |
12011651 | Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats. | 2002 May |
3 |
| 22 |
12234305 | Vasopeptidase inhibition and Ang-(1-7) in the spontaneously hypertensive rat. | 2002 Oct |
2 |
| 23 |
11300648 | Comparison of a vasopeptidase inhibitor with neutral endopeptidase and angiotensin-converting enzyme inhibitors on bradykinin metabolism in the rat coronary bed. | 2001 Apr |
2 |
| 24 |
11304511 | Vasopeptidase inhibition exhibits endothelial protection in salt-induced hypertension. | 2001 Apr |
1 |
| 25 |
11390026 | Effects of the vasopeptidase inhibitor omapatrilat on cardiac endogenous kinins in rats with acute myocardial infarction. | 2001 Jun |
2 |
| 26 |
11473654 | Vasopeptidase inhibition attenuates the progression of renal injury in subtotal nephrectomized rats. | 2001 Aug |
1 |
| 27 |
11712872 | Dual inhibition of angiotensin converting enzyme and neutral endopeptidase by omapatrilat in rat in vivo. | 2001 Nov |
3 |
| 28 |
11041166 | Antihypertensive and antihypertrophic effects of omapatrilat in SHR. | 2000 Oct |
5 |
| 29 |
10330262 | Bradykinin metabolism in the postinfarcted rat heart: role of ACE and neutral endopeptidase 24.11. | 1999 May |
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| 30 |
9544878 | Effects of omapatrilat in low, normal, and high renin experimental hypertension. | 1998 Mar |
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