| 1 |
33823318 | LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway. | 2021 Sep |
1 |
| 2 |
31969989 | The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change. | 2020 |
1 |
| 3 |
32005714 | Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment. | 2020 Apr 6 |
1 |
| 4 |
30867758 | Low-density lipoprotein receptor expression is involved in the beneficial effect of photodynamic therapy using talaporfin sodium on gastric cancer cells. | 2019 Mar |
2 |
| 5 |
31543373 | Addition of marine omega-3 fatty acids to statins in familial hypercholesterolemia does not affect in vivo or in vitro endothelial function. | 2019 Sep - Oct |
1 |
| 6 |
31706904 | Long-term effect of 2 intensive statin regimens on treatment and incidence of cardiovascular events in familial hypercholesterolemia: The SAFEHEART study. | 2019 Nov - Dec |
1 |
| 7 |
29569973 | Black Raspberry Extract Enhances LDL Uptake in HepG2 Cells by Suppressing PCSK9 Expression to Upregulate LDLR Expression. | 2018 Jun |
2 |
| 8 |
28812343 | Xanthohumol Suppresses Mylip/Idol Gene Expression and Modulates LDLR Abundance and Activity in HepG2 Cells. | 2017 Sep 13 |
1 |
| 9 |
27358845 | Low-density lipoprotein receptors play an important role in the inhibition of prostate cancer cell proliferation by statins. | 2016 Jun |
3 |
| 10 |
22528129 | Pharmacogenetic aspects in familial hypercholesterolemia with the special focus on FHMarburg (FH p.W556R). | 2012 Jun |
4 |
| 11 |
22761797 | The importance of LDL and cholesterol metabolism for prostate epithelial cell growth. | 2012 |
1 |
| 12 |
20946921 | A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells. | 2011 Jan 20 |
1 |
| 13 |
20413733 | Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin. | 2010 Jul |
6 |
| 14 |
17980884 | Effects of ezetimibe and/or simvastatin on LDL receptor protein expression and on LDL receptor and HMG-CoA reductase gene expression: a randomized trial in healthy men. | 2008 May |
4 |
| 15 |
18547436 | Plasma PCSK9 levels are significantly modified by statins and fibrates in humans. | 2008 Jun 11 |
1 |
| 16 |
18640378 | Combination of simvastatin with berberine improves the lipid-lowering efficacy. | 2008 Aug |
2 |
| 17 |
17079794 | Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor. | 2007 Feb |
1 |
| 18 |
16545796 | Pharmacological characterization in vitro of EP2306 and EP2302, potent inhibitors of squalene synthase and lipid biosynthesis. | 2006 Mar 27 |
1 |
| 19 |
14969613 | Effect of simvastatin in familial hypercholesterolemia on the affinity of electronegative low-density lipoprotein subfractions to the low-density lipoprotein receptor. | 2004 Feb 15 |
9 |
| 20 |
11849659 | Influence of LDL receptor gene mutation and apo E polymorphism on lipoprotein response to simvastatin treatment among adolescents with heterozygous familial hypercholesterolemia. | 2002 Feb |
2 |
| 21 |
12204807 | Baseline lipid values partly determine the response to high-dose simvastatin in patients with familial hypercholesterolemia. The examination of probands and relatives in Statin studies with familial hypercholesterolemia (ExPRESS FH). | 2002 Oct |
2 |
| 22 |
12208479 | The effects of lovastatin and simvastatin on the diurnal periodicity of plasma mevalonate concentrations in patients with heterozygous familial hypercholesterolemia. | 2002 Nov |
1 |
| 23 |
12505222 | Early statin therapy restores endothelial function in children with familial hypercholesterolemia. | 2002 Dec 18 |
7 |
| 24 |
11181283 | [Influence of FH Valencia 1 and 2 mutations of the LDL receptor gene on the response to simvastatin in subjects with molecularly defined heterozygous familial hypercholesterolemia in Spain]. | 2001 Jan 27 |
2 |
| 25 |
11600564 | Genetic diagnosis of familial hypercholesterolemia in a South European outbreed population: influence of low-density lipoprotein (LDL) receptor gene mutations on treatment response to simvastatin in total, LDL, and high-density lipoprotein cholesterol. | 2001 Oct |
2 |
| 26 |
10669649 | Stanol ester margarine alone and with simvastatin lowers serum cholesterol in families with familial hypercholesterolemia caused by the FH-North Karelia mutation. | 2000 Feb |
1 |
| 27 |
11480454 | Relative induction of mRNA for HMG CoA reductase and LDL receptor by five different HMG-CoA reductase inhibitors in cultured human cells. | 2000 |
1 |
| 28 |
9920155 | Association between low-density lipoprotein composition and its metabolism in non-insulin-dependent diabetes mellitus. | 1999 Jan |
1 |
| 29 |
10208479 | The type of mutation in the low density lipoprotein receptor gene influences the cholesterol-lowering response of the HMG-CoA reductase inhibitor simvastatin in patients with heterozygous familial hypercholesterolaemia. | 1999 Mar |
1 |
| 30 |
10493153 | [The RICO rat (genetically hypercholesteremic): a good model for testing a food substance or a drug specific for a key enzyme of cholesterol metabolism]. | 1999 Jul-Aug |
1 |
| 31 |
10498134 | Effect of simvastatin treatment on the electronegative low-density lipoprotein present in patients with heterozygous familial hypercholesterolemia. | 1999 Sep 15 |
3 |
| 32 |
9633944 | Association of specific LDL receptor gene mutations with differential plasma lipoprotein response to simvastatin in young French Canadians with heterozygous familial hypercholesterolemia. | 1998 Jun |
8 |
| 33 |
8831932 | Familial defective apolipoprotein B-100 (FDB): effect of simvastatin therapy on LDL-receptor binding. | 1996 Aug 23 |
2 |
| 34 |
8980885 | Effects of simvastatin on the number and composition of apoproteinB-containing lipoproteins in hypercholesterolemia: analysis of apoproteinB in each lipoprotein fraction by highly sensitive latex method. | 1996 Oct |
1 |
| 35 |
8546515 | Response to drugs and diet in a compound heterozygote for familial hypercholesterolaemia. | 1995 Dec |
1 |
| 36 |
8292093 | Cholesterol-lowering drug therapy in a patient with receptor-negative homozygous familial hypercholesterolaemia. | 1993 Nov |
2 |
| 37 |
8292099 | The effects of hypercholesterolaemia, simvastatin and dietary fat on the low density lipoprotein receptor of unstimulated mononuclear cells. | 1993 Nov |
2 |
| 38 |
8457250 | Influence of specific mutations at the LDL-receptor gene locus on the response to simvastatin therapy in Afrikaner patients with heterozygous familial hypercholesterolaemia. | 1993 Jan 4 |
1 |
| 39 |
10146335 | Plasma exchange for homozygous familial hypercholesterolaemia: the Cape Town experience. | 1993 Jul |
1 |
| 40 |
1627634 | Regulation of HMG-CoA reductase, apoprotein-B and LDL receptor gene expression by the hypocholesterolemic drugs simvastatin and ciprofibrate in Hep G2, human and rat hepatocytes. | 1992 Jul 9 |
3 |
| 41 |
1880219 | Lecithin: cholesterol acyltransferase activity in familial hypercholesterolemia treated with simvastatin and simvastatin plus low-dose colestipol. | 1991 Jun |
2 |
| 42 |
2083515 | Simvastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. | 1990 Oct |
3 |
| 43 |
2112479 | The effects of simvastatin on plasma lipoproteins and cholesterol homeostasis in patients with heterozygous familial hypercholesterolaemia. | 1990 Apr |
1 |
| 44 |
2390138 | Influence of apo E polymorphism on the response to simvastatin treatment in patients with heterozygous familial hypercholesterolemia. | 1990 Jul |
3 |