| 1 |
35427216 | Mining of molecular insights of CYP2A6 and its variants complex with coumarin (CYP2A6*-coumarin) using molecular dynamics simulation. | 2022 Apr 15 |
8 |
| 2 |
33703988 | Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13. | 2021 Nov |
1 |
| 3 |
31882454 | From Genotype to Phenotype: Content and Activities of Cytochromes P450 2A6 in Human Liver In Vitro and Predicted In Vivo. | 2020 Mar |
1 |
| 4 |
30048196 | Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes. | 2019 Jul |
1 |
| 5 |
31163215 | Inhibition of human cytochrome P450 2A6 by 7-hydroxycoumarin analogues: Analysis of the structure-activity relationship and isoform selectivity. | 2019 Aug 1 |
2 |
| 6 |
31845612 | Cancer Hazard Identification Integrating Human Variability: The Case of Coumarin. | 2019 Nov/Dec |
2 |
| 7 |
27815364 | Predictors of Variation in CYP2A6 mRNA, Protein, and Enzyme Activity in a Human Liver Bank: Influence of Genetic and Nongenetic Factors. | 2017 Jan |
1 |
| 8 |
27974382 | Functional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities. | 2017 Mar |
5 |
| 9 |
28391849 | Analysis of small biomolecules and xenobiotic metabolism using converted graphene-like monolayer plates and laser desorption/ionization time-of-flight mass spectrometry. | 2017 Jun 1 |
2 |
| 10 |
29087786 | Strategies for Avoiding Benzopyrone Hepatotoxicity in Lymphedema Management-The Role of Pharmacogenetics, Metabolic Enzyme Gene Identification, and Patient Selection. | 2017 Dec |
1 |
| 11 |
26829614 | Prediction of the metabolic clearance of benzophenone-2, and its interaction with isoeugenol and coumarin using cryopreserved human hepatocytes in primary culture. | 2016 Apr |
1 |
| 12 |
27128896 | Inhibitory Effects of Aschantin on Cytochrome P450 and Uridine 5'-diphospho-glucuronosyltransferase Enzyme Activities in Human Liver Microsomes. | 2016 Apr 27 |
1 |
| 13 |
25857233 | Inhibition effects of Vernonia cinerea active compounds against cytochrome P450 2A6 and human monoamine oxidases, possible targets for reduction of tobacco dependence. | 2015 Apr |
2 |
| 14 |
26409144 | Comprehensive assessment of Cytochrome P450 reactions: A multiplex approach using real-time ESI-MS. | 2015 Dec |
1 |
| 15 |
24475091 | Inhibitory potency of 8-methoxypsoralen on cytochrome P450 2A6 (CYP2A6) allelic variants CYP2A6 15, CYP2A6 16, CYP2A6 21 and CYP2A6 22: differential susceptibility due to different sequence locations of the mutations. | 2014 |
5 |
| 16 |
24527722 | Electrochemical detection of human cytochrome P450 2A6 inhibition: a step toward reducing dependence on smoking. | 2014 Mar 4 |
6 |
| 17 |
25343290 | Directed-evolution analysis of human cytochrome P450 2A6 for enhanced enzymatic catalysis. | 2014 |
1 |
| 18 |
25458499 | Rational design of novel CYP2A6 inhibitors. | 2014 Dec 1 |
1 |
| 19 |
23112005 | Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants. | 2013 Mar |
1 |
| 20 |
23902929 | Synthetic models related to methoxalen and menthofuran-cytochrome P450 (CYP) 2A6 interactions. benzofuran and coumarin derivatives as potent and selective inhibitors of CYP2A6. | 2013 |
2 |
| 21 |
24250937 | Inter-individual Variability of Coumarin 7-hydroxylation (CYP2A6 activity) in an Iranian Population. | 2013 Apr |
1 |
| 22 |
22382327 | Functional characterization of allelic variants of polymorphic human cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35). | 2012 |
4 |
| 23 |
22696418 | Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes. | 2012 Sep |
1 |
| 24 |
22706231 | CYP2A6: genetics, structure, regulation, and function. | 2012 May 5 |
2 |
| 25 |
20887713 | Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2. | 2011 Jan 15 |
1 |
| 26 |
21058395 | Exploring coumarin egress channels in human cytochrome P450 2A6 by random acceleration and steered molecular dynamics simulations. | 2011 Jan |
5 |
| 27 |
21418183 | Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo. | 2011 Jul |
1 |
| 28 |
21964418 | Characterization of inhibitory effects of perfluorooctane sulfonate on human hepatic cytochrome P450 isoenzymes: focusing on CYP2A6. | 2011 Nov 15 |
1 |
| 29 |
20402563 | In vitro modulation of naturally occurring flavonoids on cytochrome P450 2A6 (CYP2A6) activity. | 2010 Jul |
2 |
| 30 |
20929430 | A novel CYP2A26 identified in cynomolgus monkey liver metabolizes coumarin. | 2010 Sep |
1 |
| 31 |
19082995 | CYP2A6 genotypes and coumarin-oxidation phenotypes in a Thai population and their relationship to tobacco smoking. | 2009 Apr |
1 |
| 32 |
19251817 | Key residues controlling binding of diverse ligands to human cytochrome P450 2A enzymes. | 2009 Jun |
2 |
| 33 |
18216723 | A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent. | 2008 Jan |
1 |
| 34 |
18840518 | Differences in simulated liver concentrations of toxic coumarin metabolites in rats and different human populations evaluated through physiologically based biokinetic (PBBK) modeling. | 2008 Dec |
3 |
| 35 |
17178771 | CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline. | 2007 Mar |
1 |
| 36 |
17237153 | Inhibitory effects of neurotransmitters and steroids on human CYP2A6. | 2007 Apr |
2 |
| 37 |
17286538 | CYP2A6 polymorphisms: is there a role for pharmacogenomics in preventing coumarin-induced hepatotoxicity in lymphedema patients? | 2007 Feb |
3 |
| 38 |
17646279 | Human CYP2A6 is induced by estrogen via estrogen receptor. | 2007 Oct |
1 |
| 39 |
16378601 | 3'-UTR polymorphism in the human CYP2A6 gene affects mRNA stability and enzyme expression. | 2006 Feb 10 |
3 |
| 40 |
16490810 | Isoflavones inhibit nicotine C-oxidation catalyzed by human CYP2A6. | 2006 Mar |
1 |
| 41 |
16719377 | Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation. | 2006 |
3 |
| 42 |
16946554 | Characterization of humanized liver from chimeric mice using coumarin as a human CYP2A6 and mouse CYP2A5 probe. | 2006 Aug |
2 |
| 43 |
17220563 | In vivo evaluation of coumarin and nicotine as probe drugs to predict the metabolic capacity of CYP2A6 due to genetic polymorphism in Thais. | 2006 Dec |
4 |
| 44 |
15998359 | Porcine CYP2A polymorphisms and activity. | 2005 Aug |
3 |
| 45 |
16000056 | Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema. | 2005 Summer |
2 |
| 46 |
16086027 | Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen. | 2005 Sep |
2 |
| 47 |
16126166 | Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6. | 2005 Dec 9 |
1 |
| 48 |
16207711 | Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis. | 2005 Dec 2 |
1 |
| 49 |
16601787 | Comparison of "high throughput" micromethods for determination of cytochrome P450 activities with classical methods using HPLC for product identification. | 2005 Dec |
2 |
| 50 |
15041069 | Effects of chronic exposure to low-level cadmium on renal tubular function and CYP2A6-mediated coumarin metabolism in healthy human subjects. | 2004 Mar 21 |
2 |