Nicotine

cytochrome P450 family 2 subfamily A member 6 ; Homo sapiens







240 Article(s)
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101 22700965 Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes. 2012 Aug 3 3
102 22706231 CYP2A6: genetics, structure, regulation, and function. 2012 May 5 3
103 23049750 Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population. 2012 2
104 20887713 Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2. 2011 Jan 15 1
105 21149643 Genetic polymorphism and toxicology--with emphasis on cytochrome p450. 2011 Mar 1
106 21266057 Design, baseline characteristics, and retention of African American light smokers into a randomized trial involving biological data. 2011 Jan 25 1
107 21443033 Relationship between CYP2A6 genetic polymorphism, as a marker of nicotine metabolism, and ulcerative colitis. 2011 Feb 3
108 21513309 Catalytic mechanism of cytochrome P450 for 5'-hydroxylation of nicotine: fundamental reaction pathways and stereoselectivity. 2011 May 18 12
109 21597399 The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. 2011 Jul 7
110 21747048 Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. 2011 Sep 7 3
111 21919071 Urinary biomarkers for secondhand smoke. 2011 2
112 21964962 Interaction between heavy smoking and CYP2A6 genotypes on type 2 diabetes and its possible pathways. 2011 Dec 1
113 22019468 Identification of novel CYP2A6 inhibitors by virtual screening. 2011 Dec 1 1
114 22046326 'Smoking genes': a genetic association study. 2011 1
115 20012030 Hepatic CYP2A6 levels and nicotine metabolism: impact of genetic, physiological, environmental, and epigenetic factors. 2010 Mar 2
116 20136358 New CYP2A6 gene deletion and conversion variants in a population of Black African descent. 2010 Feb 3
117 20307138 Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism. 2010 Jun 1
118 20438369 Association between nicotine metabolism and CYP2A6*1 and CYP2A6*4 genotypes in an Iranian population. 2010 Jul 6
119 20717551 Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population. 2010 Jul 4
120 19090569 Conceptual DFT properties-based 3D QSAR: analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme. 2009 Sep 1
121 19184652 Molecular genetics of nicotine metabolism. 2009 3
122 19279561 Association of nicotine metabolite ratio and CYP2A6 genotype with smoking cessation treatment in African-American light smokers. 2009 Jun 4
123 19300303 Genetic and environmental influences on the ratio of 3'hydroxycotinine to cotinine in plasma and urine. 2009 May 1
124 19365400 A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo. 2009 Aug 3
125 19434638 Synthesis and in vitro activity of heterocyclic inhibitors of CYP2A6 and CYP2A13, two cytochrome P450 enzymes present in the respiratory tract. 2009 Jun 15 1
126 19702528 Structure, function, regulation and polymorphism of human cytochrome P450 2A6. 2009 Sep 2
127 19793020 A review of smoking behavior and smokers evidence (chemical modification, inducing nicotine metabolism, and individual variations by genotype: dopaminergic function and personality traits). 2009 5
128 19959692 Utility and relationships of biomarkers of smoking in African-American light smokers. 2009 Dec 1
129 21784037 The influence of CYP2A6 polymorphisms and cadmium on nicotine metabolism in Thai population. 2009 Nov 2
130 17522595 Identification of novel CYP2A6*1B variants: the CYP2A6*1B allele is associated with faster in vivo nicotine metabolism. 2008 Jan 8
131 17923852 Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme--an in silico approach. 2008 Oct 4
132 17978169 Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter. 2008 Feb 1
133 18065502 Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice. 2008 Mar 3
134 18098062 Nicotine metabolism and urinary elimination in mouse: in vitro and in vivo. 2008 Jan 1
135 18216723 A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent. 2008 Jan 2
136 18360915 Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent. 2008 May 3
137 18559554 Stability of the nicotine metabolite ratio in ad libitum and reducing smokers. 2008 Jun 2
138 18779312 Key residues controlling phenacetin metabolism by human cytochrome P450 2A enzymes. 2008 Dec 1
139 18976031 CYP2A6 allele frequencies in an Iranian population. 2008 Nov 1
140 19029401 Nicotine metabolism in three ethnic/racial groups with different risks of lung cancer. 2008 Dec 6
141 17130279 The role of CYP2A6 in the emergence of nicotine dependence in adolescents. 2007 Jan 1
142 17161559 Nicotine metabolism and CYP2A6 activity in a population of black African descent: impact of gender and light smoking. 2007 Jun 15 2
143 17178771 CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline. 2007 Mar 1
144 17206525 Prediction methods for nicotine clearance using cotinine and 3-hydroxy-cotinine spot saliva samples II. Model application. 2007 Feb 2
145 17237153 Inhibitory effects of neurotransmitters and steroids on human CYP2A6. 2007 Apr 1
146 17267622 A novel duplication type of CYP2A6 gene in African-American population. 2007 Apr 4
147 17620343 Mechanism-based inactivation of cytochrome P450 2A6 by decursinol angelate isolated from Angelica Gigas. 2007 Oct 1
148 17646279 Human CYP2A6 is induced by estrogen via estrogen receptor. 2007 Oct 1
149 17934923 CYP2A6 gene polymorphism and personality traits for NEO-FFI on the smoking behavior of youths. 2007 1
150 17979512 Genetic variability in CYP2A6 and the pharmacokinetics of nicotine. 2007 Oct 1