| 51 |
25416559 | CYP2A6 reduced activity gene variants confer reduction in lung cancer risk in African American smokers--findings from two independent populations. | 2015 Jan |
1 |
| 52 |
25655887 | Pharmacogenetics of nicotine and associated smoking behaviors. | 2015 |
2 |
| 53 |
25857233 | Inhibition effects of Vernonia cinerea active compounds against cytochrome P450 2A6 and human monoamine oxidases, possible targets for reduction of tobacco dependence. | 2015 Apr |
4 |
| 54 |
25862079 | The allele frequency of CYP2A6*4 in four ethnic groups of China. | 2015 Jun |
1 |
| 55 |
25998026 | Altered cytochrome P450 activities and expression levels in the liver and intestines of the monosodium glutamate-induced mouse model of human obesity. | 2015 Jul 15 |
1 |
| 56 |
26014804 | Nicotine metabolite ratio (3-hydroxycotinine/cotinine) in plasma and urine by different analytical methods and laboratories: implications for clinical implementation. | 2015 Aug |
2 |
| 57 |
26060595 | CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence. | 2015 |
18 |
| 58 |
26100465 | Electronic cigarettes: The nicotyrine hypothesis. | 2015 Sep |
3 |
| 59 |
26132489 | Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption. | 2015 |
2 |
| 60 |
26272810 | Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism. | 2015 Nov |
4 |
| 61 |
26370685 | EFFECT OF CYP2A6*4 GENETIC POLYMORPHISMS ON SMOKING BEHAVIORS AND NICOTINE DEPENDENCE IN A GENERAL POPULATION OF JAPANESE MEN. | 2015 |
4 |
| 62 |
26407342 | A Genome-Wide Association Study of a Biomarker of Nicotine Metabolism. | 2015 |
1 |
| 63 |
24033696 | Pharmacotherapy effects on smoking cessation vary with nicotine metabolism gene (CYP2A6). | 2014 Jan |
4 |
| 64 |
24045616 | Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms. | 2014 Jan 15 |
1 |
| 65 |
24448396 | Variation in P450 oxidoreductase (POR) A503V and flavin-containing monooxygenase (FMO)-3 E158K is associated with minor alterations in nicotine metabolism, but does not alter cigarette consumption. | 2014 Mar |
1 |
| 66 |
24527722 | Electrochemical detection of human cytochrome P450 2A6 inhibition: a step toward reducing dependence on smoking. | 2014 Mar 4 |
3 |
| 67 |
24631364 | Binding free energies for nicotine analogs inhibiting cytochrome P450 2A6 by a combined use of molecular dynamics simulations and QM/MM-PBSA calculations. | 2014 Apr 1 |
3 |
| 68 |
24859605 | Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. | 2014 Oct |
4 |
| 69 |
24983901 | Nicotine causes genotoxic damage but is not metabolized during long-term exposure of human nasal miniorgan cultures. | 2014 Aug 17 |
1 |
| 70 |
25220663 | Smilax China root extract detoxifies nicotine by reducing reactive oxygen species and inducing CYP2A6. | 2014 Oct |
3 |
| 71 |
25343290 | Directed-evolution analysis of human cytochrome P450 2A6 for enhanced enzymatic catalysis. | 2014 |
1 |
| 72 |
25446842 | Single tube genotyping of CYP2A6 gene deletion based on copy number determination by quantitative real-time PCR. | 2014 Dec |
1 |
| 73 |
25458499 | Rational design of novel CYP2A6 inhibitors. | 2014 Dec 1 |
1 |
| 74 |
22934830 | Cytochrome P450 2A isoenzymes in freshly prepared blood lymphocytes isolated from rats and validation as a biomarker for clinical studies in humans. | 2013 Apr |
2 |
| 75 |
23027621 | Alaska Native smokers and smokeless tobacco users with slower CYP2A6 activity have lower tobacco consumption, lower tobacco-specific nitrosamine exposure and lower tobacco-specific nitrosamine bioactivation. | 2013 Jan |
2 |
| 76 |
23112005 | Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants. | 2013 Mar |
1 |
| 77 |
23203414 | Association between CYP2A6 genetic polymorphisms and lung cancer: a meta-analysis of case-control studies. | 2013 Mar |
1 |
| 78 |
23211429 | Effects upon in-vivo nicotine metabolism reveal functional variation in FMO3 associated with cigarette consumption. | 2013 Feb |
4 |
| 79 |
23292114 | A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele. | 2013 Mar |
2 |
| 80 |
23303461 | Catalytic mechanism of cytochrome P450 for N-methylhydroxylation of nicotine: reaction pathways and regioselectivity of the enzymatic nicotine oxidation. | 2013 Mar 21 |
2 |
| 81 |
23371292 | The ability of plasma cotinine to predict nicotine and carcinogen exposure is altered by differences in CYP2A6: the influence of genetics, race, and sex. | 2013 Apr |
1 |
| 82 |
23462429 | CYP2A6 slow nicotine metabolism is associated with increased quitting by adolescent smokers. | 2013 Apr |
2 |
| 83 |
23528144 | CYP2A6 genotype and smoking behavior in current smokers screened for lung cancer. | 2013 May |
1 |
| 84 |
23530019 | Nicotine kinetics in zebra finches in vivo and in vitro. | 2013 Jun |
1 |
| 85 |
23674838 | Stability of the nicotine metabolite ratio in smokers of progressively reduced nicotine content cigarettes. | 2013 Nov |
2 |
| 86 |
23714690 | CYP2A6 genotype but not age determines cotinine half-life in infants and children. | 2013 Sep |
1 |
| 87 |
23821941 | [Absorption, metabolism and excretion of nicotine in humans]. | 2013 |
1 |
| 88 |
23933970 | Genetic and pharmacokinetic determinants of response to transdermal nicotine in white, black, and Asian nonsmokers. | 2013 Dec |
2 |
| 89 |
23936477 | Variation in trans-3'-hydroxycotinine glucuronidation does not alter the nicotine metabolite ratio or nicotine intake. | 2013 |
5 |
| 90 |
24192532 | The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans. | 2013 Dec |
3 |
| 91 |
24260284 | CYP2B6 non-coding variation associated with smoking cessation is also associated with differences in allelic expression, splicing, and nicotine metabolism independent of common amino-acid changes. | 2013 |
1 |
| 92 |
22160797 | Relationship between amounts of daily cigarette consumption and abdominal obesity moderated by CYP2A6 genotypes in Chinese male current smokers. | 2012 Apr |
1 |
| 93 |
22218454 | Substituted heteroaromatic compounds: effect on nicotine self-administration in rats. | 2012 Jun |
3 |
| 94 |
22342802 | Genetic variation in CYP2A6 predicts neural reactivity to smoking cues as measured using fMRI. | 2012 May 1 |
1 |
| 95 |
22382327 | Functional characterization of allelic variants of polymorphic human cytochrome P450 2A6 (CYP2A6*5, *7, *8, *18, *19, and *35). | 2012 |
4 |
| 96 |
22486895 | Inhibition and inactivation of cytochrome P450 2A6 and cytochrome P450 2A13 by menthofuran, β-nicotyrine and menthol. | 2012 May 30 |
2 |
| 97 |
22498344 | An LC-MS/MS method for concurrent determination of nicotine metabolites and the role of CYP2A6 in nicotine metabolite-mediated oxidative stress in SVGA astrocytes. | 2012 Sep 1 |
9 |
| 98 |
22552800 | Reproducibility of the nicotine metabolite ratio in cigarette smokers. | 2012 Jul |
2 |
| 99 |
22569203 | CYP2A6 and CYP2B6 genetic variation and its association with nicotine metabolism in South Western Alaska Native people. | 2012 Jun |
5 |
| 100 |
22676413 | Cytochrome P450-catalyzed degradation of nicotine: fundamental parameters determining hydroxylation by cytochrome P450 2A6 at the 5'-carbon or the n-methyl carbon. | 2012 Jul 12 |
1 |