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20405253 | Relapsed APL patient with variant NPM-RARalpha fusion responded to arsenic trioxide-based therapy and achieved long-term survival. | 2010 May |
5 |
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1 |
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2 |
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20574048 | Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. | 2010 Sep 30 |
3 |
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20609355 | PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3. | 2010 Jul 13 |
1 |
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20615082 | Arsenic trioxide cooperates with all trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML-RARalpha negative human myeloblastic leukemia cells. | 2010 Sep |
5 |
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1 |
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1 |
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18408733 | Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway. | 2008 May |
1 |
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18636556 | PML/RARalpha fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: Mechanisms involve the impairment of cAMP signaling and the aberrant regulation of NADPH oxidase. | 2008 Nov |
5 |
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1 |
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3 |
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16331271 | Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. | 2006 Mar 23 |
2 |
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16891316 | ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. | 2006 Sep 29 |
4 |
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17018029 | Anion exchanger 2 mediates the action of arsenic trioxide. | 2006 Sep |
1 |
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1 |
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15781666 | 19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia. | 2005 Mar 15 |
4 |
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3 |
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4 |
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12895391 | Monitoring PML-RARalpha in acute promyelocytic leukemia. | 2003 Sep |
1 |
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14534537 | Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis. | 2003 Oct 9 |
3 |
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14668793 | Arsenic enhances the activation of Stat1 by interferon gamma leading to synergistic expression of IRF-1. | 2003 Dec 11 |
1 |
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1 |
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12429934 | Arsenic trioxide arrests cells early in mitosis leading to apoptosis. | 2002 May-Jun |
1 |
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2 |
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11172537 | Treatment of acute promyelocytic leukemia with arsenic compounds: in vitro and in vivo studies. | 2001 Jan |
2 |
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11413191 | Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation. | 2001 Jun 18 |
3 |
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11704854 | Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission. | 2001 Oct 29 |
1 |
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11779431 | Effect of all-trans retinoic acid and arsenic trioxide on tissue factor expression in acute promyelocytic leukemia cells. | 2001 Jan |
1 |
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10830735 | Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: an useful salvage therapy. | 2000 Jul |
1 |
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10910048 | BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity. | 2000 Jul 1 |
2 |
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11775865 | [Potentiation of arsenic trioxide-induced apoptosis by retinoic acid in retinoic acid sensitive and resistant HL-60 myeloid leukemia cells]. | 2000 Jun |
1 |
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11798775 | [Effects of arsenic trioxide on K562 cells stably expressing two promyelocytic leukemia-specific fusion proteins]. | 2000 Apr |
4 |
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10373566 | PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. | 1999 Jul |
5 |
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9450572 | Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. | 1998 Jan 21 |
1 |
| 88 |
9596679 | Combined arsenic and retinoic acid treatment enhances differentiation and apoptosis in arsenic-resistant NB4 cells. | 1998 Jun 1 |
4 |
| 89 |
9716575 | Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner. | 1998 Sep 1 |
3 |
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9535176 | Acute promyelocytic leukemia: cellular and molecular basis of differentiation and apoptosis. | 1997 Oct-Dec |
2 |
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15622748 | [Effects of arsenic trioxide on the subcellular localization of PML/PML-RARalpha protein in leukemic cells]. | 1997 Jan |
4 |