Hyaluronic Acid

hyaluronan synthase 2 ; Homo sapiens







89 Article(s)
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1 35395768 Connective tissue growth factor mediates bone morphogenetic protein 2-induced increase in hyaluronan production in luteinized human granulosa cells. 2022 Apr 8 2
2 35403677 Activin a promotes hyaluronan production and upregulates versican expression in human granulosa cells via the ALK4-SMAD2/3-SMAD4 signaling pathway. 2022 Apr 9 3
3 35593963 Human Identical Sequences, hyaluronan, and hymecromone ─ the new mechanism and management of COVID-19. 2022 May 20 1
4 32551924 Effect of Prostaglandin D2 on mRNA Expression of Three Isoforms of Hyaluronic Acid Synthase in Nasal Polyp Fibroblasts. 2021 Jan 1
5 34504153 Heterologous production of hyaluronic acid in Nicotiana tabacum hairy roots expressing a human hyaluronan synthase 2. 2021 Sep 9 1
6 31276783 Intracellular hyaluronan: Importance for cellular functions. 2020 May 2
7 31826652 Shear Stress Regulation of Endothelial Glycocalyx Structure Is Determined by Glucobiosynthesis. 2020 Feb 1
8 32084457 Autophagic degradation of HAS2 in endothelial cells: A novel mechanism to regulate angiogenesis. 2020 Aug 1
9 32795674 Inhibition of glycolysis by targeting lactate dehydrogenase A facilitates hyaluronan synthase 2 synthesis in synovial fibroblasts of temporomandibular joint osteoarthritis. 2020 Dec 1
10 29425696 The pericellular hyaluronan of articular chondrocytes. 2019 May 3
11 29673760 Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors. 2019 May 3
12 30456933 Novel prognostic markers within the CD44-stromal ligand network in pancreatic cancer. 2019 Apr 2
13 30819231 HAS2-AS1 is a novel LH/hCG target gene regulating HAS2 expression and enhancing cumulus cells migration. 2019 Feb 28 2
14 30935974 Melanocyte Hyaluronan Coat Fragmentation Enhances the UVB-Induced TLR-4 Receptor Signaling and Expression of Proinflammatory Mediators IL6, IL8, CXCL1, and CXCL10 via NF-κB Activation. 2019 Sep 1
15 31075987 α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts. 2019 May 9 1
16 31437481 TGF-β1 promotes hyaluronan synthesis by upregulating hyaluronan synthase 2 expression in human granulosa-lutein cells. 2019 Nov 2
17 29682180 Glycogen debranching enzyme (AGL) is a novel regulator of non-small cell lung cancer growth. 2018 Mar 30 4
18 30237745 In vitro study of RRS® Silisorg CE Class III medical device composed of silanol: effect on human skin fibroblasts and its clinical use. 2018 3
19 27744520 MDA-MB-231 breast cancer cell viability, motility and matrix adhesion are regulated by a complex interplay of heparan sulfate, chondroitin-/dermatan sulfate and hyaluronan biosynthesis. 2017 Jun 1
20 27903965 Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells. 2017 Jan 3 3
21 28168629 Role of HYAL1 expression in primary breast cancer in the formation of brain metastases. 2017 Apr 2
22 28188289 Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis. 2017 Mar 24 1
23 28389562 Transforming growth factor β1 (TGFβ1) regulates CD44V6 expression and activity through extracellular signal-regulated kinase (ERK)-induced EGR1 in pulmonary fibrogenic fibroblasts. 2017 Jun 23 1
24 28496038 Methylmercury induces hyaluronan synthesis in cultured human brain microvascular endothelial cells and pericytes via different mechanisms. 2017 1
25 28533273 Akt Signaling Is Sustained by a CD44 Splice Isoform-Mediated Positive Feedback Loop. 2017 Jul 15 1
26 28604766 The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function. 2017 Jun 12 2
27 29137675 Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalities. 2017 Nov 14 2
28 26490312 Loss of Glycogen Debranching Enzyme AGL Drives Bladder Tumor Growth via Induction of Hyaluronic Acid Synthesis. 2016 Mar 1 2
29 26627828 Hyaluronan Does Not Regulate Human Epidermal Keratinocyte Proliferation and Differentiation. 2016 Mar 18 2
30 26887530 Conserved miR-26b enhances ovarian granulosa cell apoptosis through HAS2-HA-CD44-Caspase-3 pathway by targeting HAS2. 2016 Feb 18 3
31 26992562 Differential activation of noncanonical SMAD2/SMAD3 signaling by bone morphogenetic proteins causes disproportionate induction of hyaluronan production in immortalized human granulosa cells. 2016 Jun 15 1
32 27169756 Hyaluronan synthase 2 is an adverse prognostic marker in androgen receptor-negative breast cancer. 2016 Dec 1
33 24590928 The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases. 2015 Aug 1
34 25366928 Up-regulation of proteoglycan 4 in temporomandibular osteoarthritic synovial cells by hyaluronic acid. 2015 Sep 1
35 25549589 Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts. 2015 Mar 2
36 25795779 Fluorescence resonance energy transfer (FRET) and proximity ligation assays reveal functionally relevant homo- and heteromeric complexes among hyaluronan synthases HAS1, HAS2, and HAS3. 2015 May 1 1
37 25843802 Identification and analysis of the promoter region of the human HAS3 gene. 2015 May 15 2
38 24057227 Tissue distribution and subcellular localization of hyaluronan synthase isoenzymes. 2014 Jan 1
39 24197137 Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation. 2014 Jan 1 3
40 24406795 Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3. 2014 Mar 1
41 24513306 Hyaluronan: biosynthesis and signaling. 2014 Aug 1
42 24527698 Differential expression of hyaluronan synthase 2 in breast carcinoma and its biological significance. 2014 Sep 2
43 24558368 A novel mutation of Hyaluronan synthase 2 gene in Chinese children with ventricular septal defect. 2014 4
44 24658508 Hyaluronan metabolism in human keratinocytes and atopic dermatitis skin is driven by a balance of hyaluronan synthases 1 and 3. 2014 Aug 2
45 24847057 Extracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes. 2014 Jun 27 1
46 25081531 HAS2 and CD44 in breast tumorigenesis. 2014 2
47 25147816 Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment. 2014 1
48 23295082 Hyaluronan: a critical regulator of endothelial-to-mesenchymal transition during cardiac valve formation. 2013 Jul 1
49 23303191 Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3. 2013 Feb 22 1
50 23493399 Hyaluronan synthesis and myogenesis: a requirement for hyaluronan synthesis during myogenic differentiation independent of pericellular matrix formation. 2013 May 3 2