| 1 |
34065652 | Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics. | 2021 May 16 |
1 |
| 2 |
34170697 | Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant. | 2021 Jul 8 |
3 |
| 3 |
31301008 | Coenzyme Binding Site Analysis of an Isopropanol Dehydrogenase with Wide Substrate Spectrum and Excellent Organic Solvent Tolerance. | 2020 Jan |
1 |
| 4 |
31548295 | Blockade of Glutathione Metabolism in IDH1-Mutated Glioma. | 2020 Jan |
2 |
| 5 |
31586008 | Alteration of Cellular Reduction Potential Will Change 64Cu-ATSM Signal With or Without Hypoxia. | 2020 Mar |
1 |
| 6 |
31869219 | Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity. | 2020 Feb 4 |
1 |
| 7 |
32111066 | NAD- and NADPH-Contributing Enzymes as Therapeutic Targets in Cancer: An Overview. | 2020 Feb 26 |
1 |
| 8 |
32373065 | Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism. | 2020 |
1 |
| 9 |
32729927 | An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity. | 2020 Aug 28 |
2 |
| 10 |
32777735 | Isocitrate dehydrogenase variants in cancer - Cellular consequences and therapeutic opportunities. | 2020 Aug |
2 |
| 11 |
32828286 | Crystal structure of bacterial L-arabinose 1-dehydrogenase in complex with L-arabinose and NADP. | 2020 Sep 10 |
1 |
| 12 |
32955829 | Enasidenib and ivosidenib in AML. | 2020 Oct |
2 |
| 13 |
30639360 | Oxalomalate reduces tumor progression in melanoma via ROS-dependent proapoptotic and antiangiogenic effects. | 2019 Mar |
1 |
| 14 |
30661088 | IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans. | 2019 Mar |
2 |
| 15 |
30857299 | Consequences of IDH1/2 Mutations in Gliomas and an Assessment of Inhibitors Targeting Mutated IDH Proteins. | 2019 Mar 9 |
2 |
| 16 |
30862724 | Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer. | 2019 Jun |
2 |
| 17 |
31139406 | Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate. | 2019 |
2 |
| 18 |
31155409 | Allogeneic Hematopoietic Cell Transplantation Outcomes in Patients Carrying Isocitrate Dehydrogenase Mutations. | 2019 Jul |
1 |
| 19 |
31208797 | Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening. | 2019 Aug 1 |
1 |
| 20 |
31888244 | Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin. | 2019 Dec 16 |
3 |
| 21 |
29320744 | Consumption of NADPH for 2-HG Synthesis Increases Pentose Phosphate Pathway Flux and Sensitizes Cells to Oxidative Stress. | 2018 Jan 9 |
3 |
| 22 |
29439493 | Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies. | 2018 Feb 11 |
2 |
| 23 |
29448107 | Decrease in the cytosolic NADP+-dependent isocitrate dehydrogenase activity through porcine sperm capacitation. | 2018 Feb 26 |
3 |
| 24 |
29651790 | Novel Insights for Inhibiting Mutant Heterodimer IDH1wt-R132H in Cancer: An In-Silico Approach. | 2018 Jun |
6 |
| 25 |
29719265 | Mutant IDH1 Promotes Glioma Formation In Vivo. | 2018 May 1 |
1 |
| 26 |
29879375 | IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity. | 2018 Jun 7 |
2 |
| 27 |
29923039 | NADP+-dependent cytosolic isocitrate dehydrogenase provides NADPH in the presence of cadmium due to the moderate chelating effect of glutathione. | 2018 Aug |
2 |
| 28 |
30004704 | Novel Modes of Inhibition of Wild-Type Isocitrate Dehydrogenase 1 (IDH1): Direct Covalent Modification of His315. | 2018 Aug 9 |
1 |
| 29 |
30140044 | Correction: Wild-type and mutated IDH1/2 enzymes and therapy responses. | 2018 Oct |
4 |
| 30 |
30249606 | Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants. | 2018 Oct 22 |
2 |
| 31 |
30355481 | Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells. | 2018 Oct 23 |
3 |
| 32 |
30381394 | Lack of evidence for substrate channeling or flux between wildtype and mutant isocitrate dehydrogenase to produce the oncometabolite 2-hydroxyglutarate. | 2018 Dec 28 |
3 |
| 33 |
30404018 | Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Cells. | 2018 Nov 6 |
1 |
| 34 |
27923831 | Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis. | 2017 Feb 15 |
3 |
| 35 |
28052098 | IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced. | 2017 |
6 |
| 36 |
28330869 | Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency. | 2017 May 12 |
3 |
| 37 |
28375741 | Isocitrate Dehydrogenase Mutation and (R)-2-Hydroxyglutarate: From Basic Discovery to Therapeutics Development. | 2017 Jun 20 |
2 |
| 38 |
28397297 | Participation of phosphofructokinase, malate dehydrogenase and isocitrate dehydrogenase in capacitation and acrosome reaction of boar spermatozoa. | 2017 Oct |
1 |
| 39 |
28564604 | Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation. | 2017 May 30 |
1 |
| 40 |
28665599 | Importance of R-CF3···O Tetrel Bonding Interactions in Biological Systems. | 2017 Jul 20 |
1 |
| 41 |
28705010 | Isocitrate dehydrogenase mutation as a therapeutic target in gliomas. | 2017 Jun |
4 |
| 42 |
28739529 | Control of the NADPH supply for oxidative stress handling in cancer cells. | 2017 Nov |
2 |
| 43 |
26749496 | Structural and functional features of the NAD(P) dependent Gfo/Idh/MocA protein family oxidoreductases. | 2016 Apr |
1 |
| 44 |
26819452 | Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer. | 2016 Apr 15 |
4 |
| 45 |
26970248 | MR spectroscopy for in vivo assessment of the oncometabolite 2-hydroxyglutarate and its effects on cellular metabolism in human brain gliomas at 9.4T. | 2016 Oct |
1 |
| 46 |
27194485 | Structural analysis of oncogenic mutation of isocitrate dehydrogenase 1. | 2016 Jun 21 |
2 |
| 47 |
27355333 | Targeting isocitrate dehydrogenase (IDH) in cancer. | 2016 May |
1 |
| 48 |
27655638 | Decreased expression of IDH1-R132H correlates with poor survival in gastrointestinal cancer. | 2016 Nov 8 |
1 |
| 49 |
28480226 | In vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation. | 2016 May |
3 |
| 50 |
25283382 | Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation. | 2015 Feb |
1 |