| Protein Name | synaptosome associated protein 25 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6616 |
| Gene Symbol | SNAP25 |
| UniProt | P60880 (SNP25_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
158
Total Number of Articles : 220 |
Description |
synaptosome associated protein 25 |
| Gene Summary |
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
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