Protein Name serine (or cysteine) peptidase inhibitor, clade E, member 1
Organism Mus musculus
Gene ID 18787
Gene Symbol

Serpine1

UniProt G5E899 (G5E899_MOUSE)
Relationships Total Number of functionally related compound(s) : 337
Total Number of Articles : 434
Description

serine (or cysteine) peptidase inhibitor, clade E, member 1

Gene Summary

Enables serine-type endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium; negative regulation of plasminogen activation; and regulation of angiogenesis. Acts upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; placenta development; and regulation of angiogenesis. Located in extracellular space. Is expressed in several structures, including aorta; extraembryonic component; liver; oocyte; and placenta. Used to study Alzheimer's disease and Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); liver disease (multiple); lung disease (multiple); and retinal vascular disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • plasminogen activator inhibitor 1
  • PAI
  • Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)
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Properties