Protein Name C-type lectin domain family 7, member a
Organism Mus musculus
Gene ID 56644
Gene Symbol

Clec7a

UniProt V9GXI5 (V9GXI5_MOUSE)
Relationships Total Number of functionally related compound(s) : 111
Total Number of Articles : 169
Description

C-type lectin domain family 7, member a

Gene Summary

Enables (1->3)-beta-D-glucan binding activity; (1->3)-beta-D-glucan immune receptor activity; and opsonin binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and response to fungus. Acts upstream of or within several processes, including phagocytosis; positive regulation of tumor necrosis factor production; and regulation of calcineurin-NFAT signaling cascade. Located in external side of plasma membrane. Is expressed in several structures, including gut; limb; musculature; spleen; and ventral grey horn. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • C-type lectin domain family 7 member A
  • C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12
  • C-type lectin superfamily member 12
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Properties