| Protein Name | leptin |
|---|---|
| Organism | Mus musculus |
| Gene ID | 16846 |
| Gene Symbol | Lep |
| UniProt | P41160 (LEP_MOUSE), Q544U0 (Q544U0_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
647
Total Number of Articles : 912 |
Description |
leptin |
| Gene Summary |
Enables DNA binding activity and hormone activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including determination of adult lifespan; regulation of protein localization; and steroid metabolic process. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and reproductive system. Used to study abdominal obesity-metabolic syndrome (multiple); obesity; steatotic liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |