| Protein Name | estrogen receptor 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24890 |
| Gene Symbol | Esr1 |
| UniProt | P06211 (ESR1_RAT), D0FYH4 (D0FYH4_RAT), A0A0G2K0D4 (A0A0G2K0D4_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
683
Total Number of Articles : 1218 |
Description |
estrogen receptor 1 |
| Gene Summary |
Enables several functions, including estrogen binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of signal transduction; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (estrogen receptor 1). [provided by Alliance of Genome Resources, May 2025] |
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