| Protein Name | platelet activating factor receptor |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 5724 |
| Gene Symbol | PTAFR |
| UniProt | P25105 (PTAFR_HUMAN), A8K7N8 (A8K7N8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
156
Total Number of Articles : 158 |
Description |
platelet activating factor receptor |
| Gene Summary |
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
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