| Protein Name | Raf-1 proto-oncogene, serine/threonine kinase |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24703 |
| Gene Symbol | Raf1 |
| UniProt | P11345 (RAF1_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
170
Total Number of Articles : 186 |
Description |
Raf-1 proto-oncogene, serine/threonine kinase |
| Gene Summary |
Enables several functions, including ATP binding activity; adenylate cyclase activator activity; and enzyme binding activity. Involved in several processes, including MAPK cascade; protein phosphorylation; and response to hypoxia. Located in cytoplasm and plasma membrane. Biomarker of pancreatic carcinoma. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, May 2025] |
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