| Protein Name | CD3 epsilon subunit of T-cell receptor complex |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 916 |
| Gene Symbol | CD3E |
| UniProt | P07766 (CD3E_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
76
Total Number of Articles : 90 |
Description |
CD3 epsilon subunit of T-cell receptor complex |
| Gene Summary |
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008] |
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