| Protein Name | activin A receptor type 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 90 |
| Gene Symbol | ACVR1 |
| UniProt | Q04771 (ACVR1_HUMAN), D3DPA4 (D3DPA4_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
158
Total Number of Articles : 117 |
Description |
activin A receptor type 1 |
| Gene Summary |
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008] |
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