| Protein Name | anti-Mullerian hormone |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 268 |
| Gene Symbol | AMH |
| UniProt | P03971 (MIS_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
401
Total Number of Articles : 666 |
Description |
anti-Mullerian hormone |
| Gene Summary |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016] |
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| Properties | |