| Protein Name | Death caspase-1 |
|---|---|
| Organism | Drosophila melanogaster |
| Gene ID | 37729 |
| Gene Symbol | Dcp-1 |
| UniProt | O02002 (CASP1_DROME) |
| Relationships |
Total Number of functionally related compound(s) :
31
Total Number of Articles : 25 |
Description |
Death caspase-1 |
| Gene Summary |
Enables BIR domain binding activity and cysteine-type endopeptidase activity. Involved in several processes, including negative regulation of cell communication; neuron remodeling; and nurse cell apoptotic process. Located in mitochondrial matrix; neuronal cell body; and neuronal ribonucleoprotein granule. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; clypeo-labral primordium; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in breast cancer; gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and neurodegenerative disease (multiple). Orthologous to several human genes including CASP3 (caspase 3). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |