Protein Name Jun proto-oncogene, AP-1 transcription factor subunit
Organism Rattus norvegicus
Gene ID 24516
Gene Symbol

Jun

UniProt P17325 (JUN_RAT)
Relationships Total Number of functionally related compound(s) : 310
Total Number of Articles : 423
Description

Jun proto-oncogene, AP-1 transcription factor subunit

Gene Summary

Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and HMG box domain binding activity. Involved in several processes, including cellular response to potassium ion starvation; positive regulation of apoptotic process; and positive regulation of nucleobase-containing compound metabolic process. Located in chromatin. Part of protein-containing complex. Used to study hypertension. Biomarker of depressive disorder and renal carcinoma. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, May 2025]

synonyms
  • transcription factor Jun
  • AP1
  • Avian sarcoma virus 17 (v-jun) oncogene homolog
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Properties