| Protein Name | inositol monophosphatase 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3612 |
| Gene Symbol | IMPA1 |
| UniProt | P29218 (IMPA1_HUMAN), A0A024R830 (A0A024R830_HUMAN), A0A140VJL8 (A0A140VJL8_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
79
Total Number of Articles : 66 |
Description |
inositol monophosphatase 1 |
| Gene Summary |
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014] |
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