CPRiL

Protein Name	eukaryotic translation initiation factor 2 alpha kinase 2
Organism	Homo sapiens
Gene ID	5610
Gene Symbol	EIF2AK2
UniProt	P19525 (E2AK2_HUMAN), Q8IW76 (Q8IW76_HUMAN)
Relationships	Total Number of functionally related compound(s) : 296 Total Number of Articles : 391
Description	eukaryotic translation initiation factor 2 alpha kinase 2
Gene Summary	The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]
synonyms	interferon-induced, double-stranded RNA-activated protein kinase P1/eIF-2A protein kinase double stranded RNA activated protein kinase eIF-2A protein kinase 2 interferon-inducible elF2alpha kinase p68 kinase protein kinase R protein kinase RNA-regulated protein kinase, interferon-inducible double stranded RNA dependent protein phosphatase 1, regulatory subunit 83 tyrosine-protein kinase EIF2AK2 DYT33 EIF2AK1 LEUDEN PKR PPP1R83 PRKR Click to show/hide the synonyms
Properties