Protein Name ATPase Na+/K+ transporting subunit alpha 3
Organism Homo sapiens
Gene ID 478
Gene Symbol

ATP1A3

UniProt P13637 (AT1A3_HUMAN), Q53ES0 (Q53ES0_HUMAN)
Relationships Total Number of functionally related compound(s) : 28
Total Number of Articles : 25
Description

ATPase Na+/K+ transporting subunit alpha 3

Gene Summary

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

synonyms
  • sodium/potassium-transporting ATPase subunit alpha-3
  • ATPase, Na+/K+ transporting, alpha 3 polypeptide
  • Na(+)/K(+) ATPase alpha(III) subunit
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Properties