| Protein Name | myotubularin related protein 3 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 8897 |
| Gene Symbol | MTMR3 |
| UniProt | Q13615 (MTMR3_HUMAN), A0A024R1I2 (A0A024R1I2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
15
Total Number of Articles : 15 |
Description |
myotubularin related protein 3 |
| Gene Summary |
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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| Properties | |