| Protein Name | prostaglandin I2 synthase |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25527 |
| Gene Symbol | Ptgis |
| UniProt | Q62969 (PTGIS_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
56
Total Number of Articles : 52 |
Description |
prostaglandin I2 synthase |
| Gene Summary |
Enables prostaglandin-I synthase activity. Involved in several processes, including cellular response to estradiol stimulus; negative regulation of smooth muscle cell proliferation; and prostaglandin biosynthetic process. Predicted to be located in caveola; endoplasmic reticulum membrane; and nucleus. Used to study cerebral infarction; congestive heart failure; ischemia (multiple); and pulmonary hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); colorectal adenoma; limb ischemia; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase). [provided by Alliance of Genome Resources, May 2025] |
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| Properties | |